Trial reportTrials2017
Different strategies for mechanical VENTilation during CardioPulmonary Bypass (CPBVENT 2014): study protocol for a randomized controlled trial.
Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02090205 (Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanical Ventilation During Cardiac Surgery, a Randomized Controlled Trial
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Clinical outcomes of early vs. late extubation following cardiac surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Trial
- Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Side-Clamping Versus Single Cross-Clamping in On-Pump CABG: Impact on Early Hematologic Outcomes and Blood Conservation.Journal of clinical medicine · 2026Article
- Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation.Intensive care medicine experimental · 2024Article
- Effect of static lung expansion on pulmonary function following cardiopulmonary bypass in children.Heliyon · 2024Article
- Three Logistic Predictive Models for the Prediction of Mortality and Major Pulmonary Complications after Cardiac Surgery.Medicina (Kaunas, Lithuania) · 2023Observational
- Intraoperative lung-protective ventilation in cardiothoracic surgeries: Paradigm and practices.Indian journal of anaesthesia · 2021Article
- 2019 EACTS/EACTA/EBCP guidelines on cardiopulmonary bypass in adult cardiac surgery.Interactive cardiovascular and thoracic surgery · 2020Article
- Article
- Celecoxib Protects Hyperoxia-Induced Lung Injury via NF-κB and AQP1.Frontiers in pediatrics · 2019Article
- Mechanical ventilation management during cardiothoracic surgery: an open challenge.Annals of translational medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no consensus on which lung-protective strategies should be used in cardiac surgery patients. Sparse and small randomized clinical and animal trials suggest that maintaining mechanical ventilation during cardiopulmonary bypass is protective on the lungs. Unfortunately, such evidence is weak as it comes from surrogate and minor clinical endpoints mainly limited to elective coronary surgery. According to the available data in the academic literature, an unquestionable standardized strategy of lung protection during cardiopulmonary bypass cannot be recommended. The purpose of the CPBVENT study is to investigate the effectiveness of different strategies of mechanical ventilation during cardiopulmonary bypass on postoperative pulmonary function and complications. METHODS/
designThe CPBVENT study is a single-blind, multicenter, randomized controlled trial. We are going to enroll 870 patients undergoing elective cardiac surgery with planned use of cardiopulmonary bypass. Patients will be randomized into three groups: (1) no mechanical ventilation during cardiopulmonary bypass, (2) continuous positive airway pressure of 5 cmH DISCUSSION: The CPBVENT trial will establish whether, and how, different ventilator strategies during cardiopulmonary bypass will have an impact on postoperative pulmonary complications and outcomes of patients undergoing cardiac surgery.
trial registrationClinicalTrials.gov, ID: NCT02090205 . Registered on 8 March 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.