ArticleTechnology in cancer research & treatment2017
Proton Grid Therapy: A Proof-of-Concept Study.
Article in Technology in cancer research & treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Proton pencil beam scanning lattice radiotherapy: technical implementation and comparison against photon-based delivery.The British journal of radiology · 2026Article
- Novel use of peak optimized particle therapy for the delivery of three-dimensional spatially fractionated radiotherapy.Frontiers in oncology · 2026Article
- Seeing the invisible: In vivo dosimetry in radiotherapy with radiacoustic IMAGING.Medical physics · 2025Review
- Emerging strategies in radiation therapy: promises and challenges of spatial fractionation, ultra-high dose rates, and nanoparticles.Journal of physics D: Applied physics · 2025Review
- Design, fabrication, commissioning, and dosimetric verification of a GRID collimator for proton SFRT on a compact proton therapy machine.Medical physics · 2025Article
- Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.International journal of radiation oncology, biology, physics · 2025Review
- Proton GRID and LATTICE treatment planning techniques for clinical liver SFRT treatments.Physics in medicine and biology · 2025Article
- Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?Frontiers in oncology · 2025Article
- Proton ARC based LATTICE radiation therapy: feasibility study, energy layer optimization and LET optimization.Physics in medicine and biology · 2024Article
- Script-based implementation of automatic grid placement for lattice stereotactic body radiation therapy.Physics and imaging in radiation oncology · 2024Article
- Sharp dose profiles for high precision proton therapy using strongly focused proton beams.Scientific reports · 2022Article
- Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy.International journal of molecular sciences · 2022Review
- What will radiation oncology look like in 2050? A look at a changing professional landscape in Europe and beyond.Molecular oncology · 2020Review
- FLASH and minibeams in radiation therapy: the effect of microstructures on time and space and their potential application to protontherapy.The British journal of radiology · 2020Review
- A Current Review of Spatial Fractionation: Back to the Future?International journal of radiation oncology, biology, physics · 2019Review
- Spatially fractionated proton minibeams.The British journal of radiology · 2019Review
- Microbeam radiation therapy - grid therapy and beyond: a clinical perspective.The British journal of radiology · 2017Review
- The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made.Practical radiation oncologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we studied the possibility of merging proton therapy with grid therapy. We hypothesized that patients with larger targets containing solid tumor growth could benefit from being treated with this method, proton grid therapy. We performed treatment planning for 2 patients with abdominal cancer with the suggested proton grid therapy technique. The proton beam arrays were cross-fired over the target volume. Circular or rectangular beam element shapes (building up the beam grids) were evaluated in the planning. An optimization was performed to calculate the fluence from each beam grid element. The optimization objectives were set to create a homogeneous dose inside the target volume with the constraint of maintaining the grid structure of the dose distribution in the surrounding tissue. The proton beam elements constituting the grid remained narrow and parallel down to large depths in the tissue. The calculation results showed that it is possible to produce target doses ranging between 100% and 130% of the prescribed dose by cross-firing beam grids, incident from 4 directions. A sensitivity test showed that a small rotation or translation of one of the used grids, due to setup errors, had only a limited influence on the dose distribution produced in the target, if 4 beam arrays were used for the irradiation. Proton grid therapy is technically feasible at proton therapy centers equipped with spot scanning systems using existing tools. By cross-firing the proton beam grids, a low tissue dose in between the paths of the elemental beams can be maintained down to the vicinity of a deep-seated target. With proton grid therapy, it is possible to produce a dose distribution inside the target volume of similar uniformity as can be created with current clinical methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.