Evidence map›Paper›PMID 28591651›Full record

ArticleStem cell reports2017

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

Andrew R Pepper, Rena Pawlick, Antonio Bruni, John Wink, Yasmin Rafiei, Doug O'Gorman, Richard Yan-Do, Boris Gala-Lopez, Tatsuya Kin, Patrick E MacDonald and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Andrew R PepperClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada; Department of Surgery, University of Alberta, 8440 Walter C Mackenzie Health Centre 112 Street, Edmonton, AB T5G 2B7, Canada.
Rena PawlickClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada.
Antonio BruniClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada; Department of Surgery, University of Alberta, 8440 Walter C Mackenzie Health Centre 112 Street, Edmonton, AB T5G 2B7, Canada.
John WinkClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada.
Yasmin RafieiClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada.
Doug O'GormanClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada.
Richard Yan-DoDepartment of Pharmacology, University of Alberta, 9-70 Medical Science Building, Edmonton, AB T6G 2H7, Canada.
Boris Gala-LopezClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada; Department of Surgery, University of Alberta, 8440 Walter C Mackenzie Health Centre 112 Street, Edmonton, AB T5G 2B7, Canada.
Tatsuya KinClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada.
Patrick E MacDonaldDepartment of Pharmacology, University of Alberta, 9-70 Medical Science Building, Edmonton, AB T6G 2H7, Canada.
A M James ShapiroClinical Islet Transplant Program, University of Alberta, 112 Street & 87 Avenue, Edmonton, AB T6G 2E1, Canada; Department of Surgery, University of Alberta, 8440 Walter C Mackenzie Health Centre 112 Street, Edmonton, AB T5G 2B7, Canada. Electronic address: amjs@islet.ca.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beta-cell replacement therapy is an effective means to restore glucose homeostasis in select humans with autoimmune diabetes. The scarcity of "healthy" human donor pancreata restricts the broader application of this effective curative therapy. "β-Like" cells derived from human embryonic stem cells (hESC), with the capacity to secrete insulin in a glucose-regulated manner, have been developed in vitro, with limitless capacity for expansion. Here we report long-term diabetes correction in mice transplanted with hESC-derived pancreatic endoderm cells (PECs) in a prevascularized subcutaneous site. This advancement mitigates chronic foreign-body response, utilizes a device- and growth factor-free approach, facilitates in vivo differentiation of PECs into glucose-responsive insulin-producing cells, and reliably restores glycemic control. Basal and stimulated human C-peptide secretion was detected throughout the study, which was abolished upon graft removal. Recipient mice demonstrated physiological clearance of glucose in response to metabolic challenge and safely retrieved grafts contained viable glucose regulatory cells.

Indexed as

AnimalsBlood GlucoseCalciumCell DifferentiationC-PeptideDiabetes Mellitus, ExperimentalEndodermHuman Embryonic Stem CellsHumansInjections, SubcutaneousInsulin-Secreting CellsMiceNeovascularization, PhysiologicOxygen ConsumptionPancreasTransplantation, HeterologousBlood GlucoseCalciumC-Peptidecellular transplantationdiabeteshuman pluripotent stem cellspancreatic endoderm cellsprevascularizedsubcutaneous

Identifiers

PMID28591651
PMCPMC5470173
OpenAlexW2621794998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.