ArticleCell metabolism2017
Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.
2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph
Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 52 papers.
0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short-Term Endogenous Hydrogen Sulfide Upregulation
Dietary Restriction in Vascular Surgery
Who cites it
52 citing papers in PubMed, 88 citations in OpenAlex.
- Bioengineered ROS-tolerant probiotic reshapes gut microbiota-host axis to ameliorate type 2 diabetes in male mice.Nature communications · 2026Article
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- Biosynthesis of HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO.Antioxidants (Basel, Switzerland) · 2025Article
- Association of Kidney Graft Long-term Outcome With Recipient Cystathionine Gamma-lyase Polymorphisms and Hydrogen Sulfide Levels: A Cohort Study.Transplantation direct · 2025Article
- Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis.Frontiers in pharmacology · 2025Article
- Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin.GeroScience · 2024Article
- Dissecting the multifaceted roles of autophagy in cancer initiation, growth, and metastasis: from molecular mechanisms to therapeutic applications.Medical oncology (Northwood, London, England) · 2024Review
- Exploring the potential of asparagine restriction in solid cancer treatment: recent discoveries, therapeutic implications, and challenges.Medical oncology (Northwood, London, England) · 2024Review
- Diet-Modifiable Redox Alterations in Ageing and Cancer.Sub-cellular biochemistry · 2024Review
- Sodium Hydrosulfide Treatment During Porcine Kidney Ex Vivo Perfusion and Transplantation.Transplantation direct · 2023Article
- Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.Aging · 2023Article
- Aging under endocrine hormone regulation.Frontiers in endocrinology · 2023Review
- A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3Journal of oncology · 2023Article
- Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation.GeroScience · 2022Article
- Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and Hydrogen Sulfide Production Capacities.Antioxidants & redox signaling · 2022Article
- Article
- New Directions in Research on Aging.Stem cell reviews and reports · 2022Article
- Early Life Interventions Can Shape Aging.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 13 institutions in 4 countries.
Christopher HineDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Hyo-Jeong KimDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Yan ZhuDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Eylul HarputlugilDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Alban LongchampDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Surgery, Heart and Vascular Center Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Marina Souza MatosDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Preeti RamadossDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Kevin BauerleDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Lear BraceDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
John M AsaraDivision of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
C Keith OzakiDepartment of Surgery, Heart and Vascular Center Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sheue-Yann ChengLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Subhankar SinghaDepartment of Chemistry, Center for Electro-Photo Behaviors in Advanced Molecular Systems, POSTECH, 77 Cheongam-Ro, Nam-Gu, Pohang 790-784, Republic of Korea.
Kyo Han AhnDepartment of Chemistry, Center for Electro-Photo Behaviors in Advanced Molecular Systems, POSTECH, 77 Cheongam-Ro, Nam-Gu, Pohang 790-784, Republic of Korea.
Alec KimmelmanDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Ffolliott M FisherDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Pavlos PissiosDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Dominic J WithersMedical Research Council Clinical Science Centre, Imperial College, London W12 0NN, UK.
Colin SelmanGlasgow Ageing Research Network, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Rui WangDepartment of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.
Kelvin YenDepartment of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Valter D LongoDepartment of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Pinchas CohenDepartment of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Andrzej BartkeDepartment of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.
John J KopchickEdison Biotechnology Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.
Richard MillerDepartment of Pathology & Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA.
Anthony N HollenbergDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: thollenb@bidmc.harvard.edu.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USUniversity of Southern California · USBrigham and Women's Hospital · USPohang University of Science and Technology · KRDana-Farber Cancer Institute · USImperial College London · GBLakehead University · CANational Institutes of Health · USOhio University · USSouthern Illinois University School of Medicine · USUniversity of Glasgow · GBUniversity of Michigan–Ann Arbor · US
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MResearch Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2MThyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9MThe Role of the Glucose-regulated Protein GRP78/BiP in Stress Resistance and AginP01AG034906 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MITCHELL, JAMES R. · 2011 to 2016
$9.3MCOREPRESSOR REGULATION OF THYROID HORMONE ACTIONR01DK056123 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N · 2000 to 2023
$7.6MLongevity genes and calorie restriction: early post-natal effectsR01AG019899 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI BARTKE, ANDRZEJ · 2001 to 2016
$6.1MMechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0MNew Targets of Thyroid Hormone ActionR01DK098525 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N · 2013 to 2017
$2.6MProtection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6MRequirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747kCorepressor Regulation of Nuclear Receptor ActionR56DK056123 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HOLLENBERG, ANTHONY N · 2009 to 2009
$425kBiotechnology and Biological Sciences Research Council BB/H012850/1Biotechnology and Biological Sciences Research Council BB/H020527/2Medical Research Council MC_U120097114NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NIA NIH HHS K99 AG050777NIA NIH HHS P30 AG024824NIA NIH HHS R00 AG050777NIA NIH HHS R01 AG019899NIA NIH HHS R01 AG036712NIA NIH HHS R56 AG036712NIDDK NIH HHS R01 DK056123NIDDK NIH HHS R01 DK090629NIDDK NIH HHS R01 DK098525NIDDK NIH HHS R56 DK056123
Abstract
Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (H
Indexed as
AnimalsCystathionine gamma-LyaseDextrothyroxineFemaleGrowth HormoneHydrogen SulfideHypothalamo-Hypophyseal SystemInsulin-Like Growth Factor ILiverMiceMice, KnockoutCystathionine gamma-LyaseDextrothyroxineGrowth HormoneHydrogen Sulfideinsulin-like growth factor-1, mouseInsulin-Like Growth Factor Iautophagycystathionine γ-lyaseFGF21growth hormonehydrogen sulfidehypopituitary dwarfismIGF-1IRS-1longevitythyroid hormone
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
NCT03303534ClinicalTrials.gov
NCT04013412ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.