Evidence map›Paper›PMID 28591585›Full record

ArticleCell reports2017

Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.

Zachary M Carico, Kingshuk Roy Choudhury, Baojun Zhang, Yuan Zhuang, Michael S Krangel

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  4. Article
  5. Inactivation of GSK3β by SerCell death and differentiation · 2025
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  13. Article
  14. Methods for Study of Mouse T Cell Receptor α and β Gene Rearrangements.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zachary M CaricoDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Kingshuk Roy ChoudhuryDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA.
Baojun ZhangDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Yuan ZhuangDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Michael S KrangelDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: krang001@mc.duke.edu.
Duke University Hospital · USDuke Medical Center · US

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
HEB MEDIATED PATHWAYS AND FUNCTION IN T CELL DEVELOPMENTR01GM059638 · NIGMS · DUKE UNIVERSITY · PI CHAN, FRANCIS KAMING · 1999 to 2021
$6.9M
HUMAN GAMMA DELTA T CELL RECEPTORR01GM041052 · NIGMS · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 1989 to 2019
$4.8M
Basic Immunology Training ProgramT32AI052077 · NIAID · DUKE UNIVERSITY · PI KRANGEL, MICHAEL S · 2002 to 2024
$4.2M
A new approach to homeostatic maintenance of dendritic epidermal T cellsR21AG045440 · NIA · DUKE UNIVERSITY · PI ZHUANG, YUAN · 2014 to 2015
$428k
NCATS NIH HHS UL1 TR001117NIAID NIH HHS T32 AI052077NIA NIH HHS R21 AG045440NIGMS NIH HHS R01 GM041052NIGMS NIH HHS R01 GM059638
6 · The paper itself

Abstract

Adaptive immunity depends on diverse T cell receptor repertoires generated by variable, diversity, and joining (V[D]J) recombination. Here, we define the principles by which combinatorial diversity is generated in the murine Tcra repertoire. Tcra and Tcrd gene segments share the Tcra-Tcrd locus, with interspersed V

Indexed as

Models, GeneticThymocytesV(D)J RecombinationAnimalsMiceMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaantigen receptorchromatin conformationMAIT cellsmucosa-associated invariant T cellsT cell developmentT cell receptor alphaT cell receptor deltaT cell receptor repertoireTCR repertoireV(D)J recombination

Identifiers

PMID28591585
PMCPMC5529038
OpenAlexW2622643754

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.