ReviewEpilepsia2017
Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity.
Review in Epilepsia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Is surgery effective for treating hypothalamic hamartoma causing isolated central precocious puberty? A systematic review.Neurosurgical review · 2021Pooled it
- Pediatric endocrine disorders: a review of intracranial findings and appropriate imaging.Pediatric radiology · 2026Review
- International Consensus on the Evaluation and Management of Hypothalamic Hamartomas: Results From a Modified Delphi Survey.Neurology · 2026Article
- Case Report: Pallister-Hall syndrome diagnosed in adulthood during evaluation of recurrent hypoglycemia.Frontiers in endocrinology · 2026Article
- Factors Affecting Sleep and Wakefulness in People with Epilepsy: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Research progress of connexins in epileptogensis.Acta epileptologica · 2025Review
- Hypothalamic Hamartomas: A Narrative Review.Biomedicines · 2025Review
- Low-Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad-Spectrum Efficacy Across Models of Epilepsy.CNS neuroscience & therapeutics · 2025Article
- Radiosurgery for Hypothalamic Gliomas: A Case Report and Clinical Guidelines Form a Neurosurgical Center of Excellence.Journal of personalized medicine · 2024Article
- Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.Epilepsia open · 2024Article
- Robot-assisted laser interstitial thermal therapy for drug-resistant epilepsy in hypothalamic hamartoma.Neurosurgical focus: Video · 2024Article
- Direct resection is a safe and effective strategy to control seizures in patients with hypothalamic hamartoma.Scientific reports · 2024Article
- Infantile Hypothalamic Hamartoma: A Rare Presentation of Isolated Obesity.JCEM case reports · 2024Article
- Central precocious puberty - etiology with particular consideration of neurological causes.Archives of medical science : AMS · 2024Article
- Multimodal Approach for the Treatment of Complex Hypothalamic Hamartomas.Advances and technical standards in neurosurgery · 2024Review
- Advances in epileptic network findings of hypothalamic hamartomas.Journal of central nervous system disease · 2024Review
- In vivo magnetic resonance spectroscopy for the differential diagnosis of a cerebral mass in a boy with precocious puberty: a case report and review of the literature.Hormones (Athens, Greece) · 2023Review
- Hypothalamic hamartoma: a cause of precocious puberty.BMJ case reports · 2023Article
- Advances in hypothalamic hamartoma research over the past 30 years (1992-2021): a bibliometric analysis.Frontiers in neurology · 2023Article
- Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam.Annals of pediatric endocrinology & metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The most common, and usually the only, endocrine disturbance in patients with hypothalamic hamartoma (HH) and epilepsy is central precocious puberty (CPP). The mechanism for CPP associated with HH may relate to ectopic generation and pulsatile release of gonadotropin-releasing hormone (GnRH) from the HH, but this remains an unproven hypothesis. Possible regulators of GnRH release that are intrinsic to HH tissue include the following: (1) glial factors (such as transforming growth factor α[TGFα) and (2) γ-aminobutyric acid (GABA)-mediated excitation. Both are known to be present in surgically-resected HH tissue, but are present in patients with and without a history of CPP, suggesting the possibility that symptoms related to HH are directly associated with the region of anatomic attachment of the HH to the hypothalamus, which determines functional network connections, rather than to differences in HH tissue expression or pathophysiology. CPP associated with HH presents with isosexual development prior to the age of 8 years in girls and 9 years in boys. It is not uncommon for CPP with HH to present in children at an earlier age in comparison to other causes of CPP, including in infancy. Surgical resection of the HH can be effective for treating CPP, but is reserved for patients with intractable epilepsy, since GnRH agonists are widely available and effective treatment. Other endocrine disturbances with HH are rare, but can include growth hormone deficiency, hypothyroidism, and adrenal insufficiency. Diabetes insipidus is commonly encountered postoperatively, but is not observed with HH prior to surgical intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.