ArticleMemorias do Instituto Oswaldo Cruz2017
Genome analysis of yellow fever virus of the ongoing outbreak in Brazil reveals polymorphisms.
Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 100 citations in OpenAlex.
- Evolution and spillover dynamics of yellow fever at the forest-urban interface in Brazil.Nature microbiology · 2026Article
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- A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity.Nature communications · 2025Article
- The Yellow Fever Outbreak in Brazil (2016-2018): How a Low Vaccination Coverage Can Contribute to Emerging Disease Outbreaks.Microorganisms · 2025Review
- Conventional RT-PCR for Yellow Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Epidemic Outbreaks Related to Yellow Fever Viruses.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Sequencing of Yellow Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Wild Brazilian yellow fever virus infection in Syrian hamsters (Mesocricetus auratus): Clinical and histopathological analyses.Virus research · 2024Article
- Review
- Characterization and Investigation of Risk Factors for Late-Relapsing Hepatitis After Yellow Fever.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- The Importance of Entomo-Virological Investigation of Yellow Fever Virus to Strengthen Surveillance in Brazil.Tropical medicine and infectious disease · 2023Article
- Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection.Science translational medicine · 2023Article
- Yellow Fever Virus Maintained byViruses · 2023Article
- Ecological, Genetic, and Phylogenetic Aspects of YFV 2017-2019 Spread in Rio de Janeiro State.Viruses · 2023Article
- Article
- Continuous Circulation of Yellow Fever among Rural Populations in the Central African Republic.Viruses · 2022Article
- Occurrence of yellow fever outbreaks in a partially vaccinated population: An analysis of the effective reproduction number.PLoS neglected tropical diseases · 2022Article
- Phenotypic and Genetic Studies of the Viral Lineage Associated with the Recent Yellow Fever Outbreak in Brazil.Viruses · 2022Article
- Mapping and Validation of Peptides Differentially Recognized by Antibodies from the Serum ofViruses · 2022Article
- Genotype-specific features reduce the susceptibility of South American yellow fever virus strains to vaccine-induced antibodies.Cell host & microbe · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current yellow fever outbreak in Brazil is the most severe one in the country in recent times. It has rapidly spread to areas where YF virus (YFV) activity has not been observed for more than 70 years and vaccine coverage is almost null. Here, we sequenced the whole YFV genome of two naturally infected howler-monkeys (Alouatta clamitans) obtained from the Municipality of Domingos Martins, state of Espírito Santo, Brazil. These two ongoing-outbreak genome sequences are identical. They clustered in the 1E sub-clade (South America genotype I) along with the Brazilian and Venezuelan strains recently characterised from infections in humans and non-human primates that have been described in the last 20 years. However, we detected eight unique amino acid changes in the viral proteins, including the structural capsid protein (one change), and the components of the viral replicase complex, the NS3 (two changes) and NS5 (five changes) proteins, that could impact the capacity of viral infection in vertebrate and/or invertebrate hosts and spreading of the ongoing outbreak.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.