ArticlePLoS computational biology2017
Mechanisms underlying a thalamocortical transformation during active tactile sensation.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 46 citations in OpenAlex.
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- Interchangeable Role of Motor Cortex and Reafference for the Stable Execution of an Orofacial Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Theory of hierarchically organized neuronal oscillator dynamics that mediate rodent rhythmic whisking.Neuron · 2022Article
- STDP and the distribution of preferred phases in the whisker system.PLoS computational biology · 2021Article
- Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inhibitory stabilization and cortical computation.Nature reviews. Neuroscience · 2021Review
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- Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.eLife · 2020Article
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- Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior.Neuron · 2019Article
- Regulation of gamma-frequency oscillation by feedforward inhibition: A computational modeling study.Hippocampus · 2019Article
- The Sensorimotor Basis of Whisker-Guided Anteroposterior Object Localization in Head-Fixed Mice.Current biology : CB · 2019Article
- Prediction of Choice from Competing Mechanosensory and Choice-Memory Cues during Active Tactile Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Design strategies for dynamic closed-loop optogenetic neurocontrol in vivo.Journal of neural engineering · 2018Article
- Neocortical dynamics during whisker-based sensory discrimination in head-restrained mice.Neuroscience · 2018Review
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During active somatosensation, neural signals expected from movement of the sensors are suppressed in the cortex, whereas information related to touch is enhanced. This tactile suppression underlies low-noise encoding of relevant tactile features and the brain's ability to make fine tactile discriminations. Layer (L) 4 excitatory neurons in the barrel cortex, the major target of the somatosensory thalamus (VPM), respond to touch, but have low spike rates and low sensitivity to the movement of whiskers. Most neurons in VPM respond to touch and also show an increase in spike rate with whisker movement. Therefore, signals related to self-movement are suppressed in L4. Fast-spiking (FS) interneurons in L4 show similar dynamics to VPM neurons. Stimulation of halorhodopsin in FS interneurons causes a reduction in FS neuron activity and an increase in L4 excitatory neuron activity. This decrease of activity of L4 FS neurons contradicts the "paradoxical effect" predicted in networks stabilized by inhibition and in strongly-coupled networks. To explain these observations, we constructed a model of the L4 circuit, with connectivity constrained by in vitro measurements. The model explores the various synaptic conductance strengths for which L4 FS neurons actively suppress baseline and movement-related activity in layer 4 excitatory neurons. Feedforward inhibition, in concert with recurrent intracortical circuitry, produces tactile suppression. Synaptic delays in feedforward inhibition allow transmission of temporally brief volleys of activity associated with touch. Our model provides a mechanistic explanation of a behavior-related computation implemented by the thalamocortical circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.