ArticlePloS one2017
Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Prognostic factors for functional decline in community-dwelling older adults with dementia: a systematic review and meta-analysis.European geriatric medicine · 2026Review
- Coevolution of Cognitive and Health Trajectories Among US Older Adults With Cognitive Impairment.Journal of the American Medical Directors Association · 2026Article
- Latent classes and progression of Mini-Mental State Examination scores in young-onset dementia: Data from the Swedish Dementia Register.Journal of Alzheimer's disease : JAD · 2025Article
- Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids.Translational psychiatry · 2024Article
- Temporal atrophy together with verbal encoding impairment is highly predictive for cognitive decline in typical Alzheimer's dementia - a retrospective follow-up study.Frontiers in psychiatry · 2024Article
- Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories.Alzheimer's research & therapy · 2023Article
- Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study.BMJ (Clinical research ed.) · 2022Article
- Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease.Alzheimer's research & therapy · 2021Article
- Influencing factors of Barthel index scores among the community-dwelling elderly in Hong Kong: a random intercept model.BMC geriatrics · 2021Article
- The Impact of the COVID-19 Pandemic on the Cognition of People with Dementia.International journal of environmental research and public health · 2021Article
- Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD · 2021Article
- The side effect profile of Clozapine in real world data of three large mental health hospitals.PloS one · 2020Article
- Multi-time-point data preparation robustly reveals MCI and dementia risk factors.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Cognitive and functional progression of dementia in two longitudinal studies.International journal of geriatric psychiatry · 2019Article
- Unfolding of hidden white blood cell count phenotypes for gene discovery using latent class mixed modeling.Genes and immunity · 2019Article
- Understanding and predicting the longitudinal course of dementia.Current opinion in psychiatry · 2019Review
- Cognitive and functional progression in Alzheimer disease: A prediction model of latent classes.International journal of geriatric psychiatry · 2018Article
- A new device-aided cognitive function test, User eXperience-Trail Making Test (UX-TMT), sensitively detects neuropsychological performance in patients with dementia and Parkinson's disease.BMC psychiatry · 2018Article
- Article
- The course of neuropsychiatric symptoms in nursing home residents from admission to 30-month follow-up.PloS one · 2018Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundModeling trajectories of decline can help describe the variability in progression of cognitive impairment in dementia. Better characterisation of these trajectories has significant implications for understanding disease progression, trial design and care planning.
methodsPatients with at least three Mini-mental State Examination (MMSE) scores recorded in the South London and Maudsley NHS Foundation Trust Electronic Health Records, UK were selected (N = 3441) to form a retrospective cohort. Trajectories of cognitive decline were identified through latent class growth analysis of longitudinal MMSE scores. Demographics, Health of Nation Outcome Scales and medications were compared across trajectories identified.
resultsFour of the six trajectories showed increased rate of decline with lower baseline MMSE. Two trajectories had similar initial MMSE scores but different rates of decline. In the faster declining trajectory of the two, a higher incidence of both behavioral problems and sertraline prescription were present.
conclusionsWe find suggestive evidence for association of behavioral problems and sertraline prescription with rate of decline. Further work is needed to determine whether trajectories replicate in other datasets.
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