ArticlePloS one2017
Hyponatremia and increased risk of dementia: A population-based retrospective cohort study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.Systematic reviews · 2023Pooled it
- Associations between serum electrolyte impairments and frailty status in older adults.International urology and nephrology · 2026Article
- Drug-Induced Hyponatremia as a Cause of Emergency Department Attendance.Pharmacy (Basel, Switzerland) · 2026Article
- The role of noninfectious comorbidities in the association between severe infections and risk of dementia in Finland: A nationwide registry study.PLoS medicine · 2026Article
- Bloodwork-free Early Screening for Alzheimer's Disease via Comorbid Pattern Recognition in Electronic Health Records.Research square · 2026Article
- Cognitive performance classification of older patients using machine learning and electronic medical records.Scientific reports · 2025Article
- Hyponatremia in geriatric patients.Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- Associations between serum sodium level ranges with geriatric syndromes.European geriatric medicine · 2025Article
- A retrospective study: exploring preoperative hyponatremia in elderly patients with hip fractures.Journal of orthopaedic surgery and research · 2024Article
- Relationship Between Dementia and Systemic Metabolic Disorders.Advances in experimental medicine and biology · 2024Article
- Serum sodium improvement: change in Comprehensive Geriatric Assessment parameters in geriatric patients with hyponatremia.BMC geriatrics · 2023Article
- Incidence trends and risk factors for hyponatremia in epilepsy patients: A large-scale real-world data study.Heliyon · 2023Article
- Serum sodium, cognition and incident dementia in the general population.Age and ageing · 2023Article
- A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke.Therapeutic advances in endocrinology and metabolism · 2023Review
- Hyponatremic Cognitive Dysfunction Resulting from Drug-Drug-Gene Interaction between Sertraline and Cannabidiol in an Intermediate CYP2C19 Metabolizer Patient.Innovations in pharmacy · 2022Article
- Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals.Frontiers in aging neuroscience · 2022Article
- Article
- Cognitive performance in relation to hydration status and water intake among older adults, NHANES 2011-2014.European journal of nutrition · 2020Article
- Lower serum sodium levels predict poor clinical outcomes in patients with insomnia.BMC nephrology · 2020Article
- [Hyponatremia in older persons (part I)-keep diagnosis simple : How to detect tricks and avoid pitfalls].Zeitschrift fur Gerontologie und Geriatrie · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyponatremia is the most common electrolyte disorder and also a predictor of mild cognition impairment. However, the association between hyponatremia and dementia in long follow up periods is rarely investigated. A retrospective cohort study was performed using the claims data of all insured residents who were covered by Taiwan's universal health insurance from 2000 to 2011. A total of 4900 hyponatremia patients and 19545 matched comparisons were recruited for the analysis. The incidences of hyponatremia and dementia were diagnosed with clinical protocol and defined using the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM). Cox proportional hazard regression and Kaplan-Meier curves were used for the analyses. Independent of adjusting factors, hyponatremia patients had 2.36-fold higher chances of suffering dementia, including Alzheimer's disease (AD) and non-AD dementia, than the comparisons. Severe hyponatremia patients had higher risks of suffering dementia than the non-severe hyponatremia patients (adjusted hazard ratio: 4.29 (95% CI: 3.47-5.31) versus 2.08 (95% CI: 1.83-2.37)). A dose response relationship was observed between hyponatremia and dementia. Those hyponatremia patients with baseline or incident stroke had significantly higher chances of suffering dementia compared with those patients without hyponatremia and stroke. Stroke is a significant modifier of the relationship between hyponatremia and dementia. Cerebrovascular disease after incident hyponatremia must be prevented to reduce the incidence of dementia.
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