Observational studyMedicine2017
Prognostic impact of hyponatremia occurring at various time points during hospitalization on mortality in patients with acute myocardial infarction.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Short- and long-term prognostic value of hyponatremia in patients with acute coronary syndrome: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Serum sodium and eplerenone use in patients with a myocardial infarction and left ventricular dysfunction or heart failure: insights from the EPHESUS trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Trial
- Hyponatremia in takotsubo syndrome is associated with attenuated in-hospital improvement of left ventricular ejection fraction and higher long-term mortality.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025Article
- Long-Term Clinical Relevance of Hyponatremia Identified During Acute Phase of Myocardial Infarction.Journal of clinical medicine · 2025Article
- Impact of Hyponatraemia at Clinical Stable-State on Survival in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Impact of low sodium values on survival outcomes of patients with cancer receiving immune checkpoint inhibitors.Immunotherapy · 2024Article
- Korean Society of Nephrology 2022 recommendations on controversial issues in diagnosis and management of hyponatremia.The Korean journal of internal medicine · 2022Review
- Korean Society of Nephrology 2022 Recommendations on controversial issues in diagnosis and management of hyponatremia.Kidney research and clinical practice · 2022Article
- Korean Society of Nephrology 2022 Recommendations on Controversial Issues in Diagnosis and Management of Hyponatremia.Electrolyte & blood pressure : E & BP · 2022Review
- Prognostic Significance of Hyponatremia in ST-elevation Myocardial Infarction/Heart Failure Patients.Cureus · 2019Review
- Hyponatremia: Prevalence and characteristics in internal medicine patients in southeast of China.Medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the incidence and prognostic impact of hyponatremia occurring at various time points during hospitalization on long-term mortality in acute myocardial infarction (AMI) survivors. We retrospectively studied 1863 patients diagnosed with AMI. Baseline, nadir, and discharge sodium levels during hospitalization were recorded and analyzed. Hyponatremia was defined as a serum sodium level <135 mEq/L. On the basis of baseline, nadir, and discharge sodium levels during hospitalization, hyponatremia was diagnosed in 309 (16.6%), 518 (27.8%), and 147 (7.9%) patients, respectively. In a multivariate Cox-proportional regression analysis, discharge sodium level had the strongest significant relationship with long-term mortality (hazard ratio [HR] as continuous variable = 1.06, 95% confidence interval [CI]: 1.01-1.11, P = .026; HR as categorical variable = 1.71; 95% CI: 1.06-2.75; P = .028), but baseline and nadir sodium had no prognostic impact on long-term mortality after adjustment. The serum sodium level and incidence of hyponatremia varied at different time points during hospitalization. In addition, the association between sodium level and long-term mortality differed at these various time points. The discharge sodium level, among the various time points, seems the best predictor of long-term mortality in AMI survivors.
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