Evidence map›Paper›PMID 28591004›Full record

ArticleThe Journal of cardiovascular nursing

Medication Adherence Mediates the Relationship Between Heart Failure Symptoms and Cardiac Event-Free Survival in Patients With Heart Failure.

Jia-Rong Wu, Debra K Moser

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07211724 (Methamphetamine Use Disorder Support in Heart Failure), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211724 nanot yet recruitingnot on this map

Methamphetamine Use Disorder Support in Heart Failure (Meth HF) Pilot Study

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2026 to 2027Enrolled50ConditionsHeart Failure, Methamphetamine Use DisorderArmsMUD Management (contingency management +/- adjunctive MUD pharmacotherapy), HF GDMT management
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jia-Rong WuJia-Rong Wu, PhD, RN Post-doctoral Fellow, School of Nursing, University of North Carolina at Chapel Hill. Debra K. Moser, PhD, RN Professor and Linda C. Gill Chair of Cardiovascular Nursing and Director, RICH Heart Program, College of Nursing, University of Kentucky, Lexington.
Debra K Moser
Royal College of Nursing · GBUniversity of North Carolina at Chapel Hill · US

Funding

A Family-Focused, Literacy-Sensitive Intervention to Improve Medication AdherenceK23NR014489 · NINR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WU, JIA-RONG · 2013 to 2015
$379k
NINR NIH HHS K23 NR014489
6 · The paper itself

Abstract

backgroundHeart failure (HF) symptoms such as dyspnea are common and may precipitate hospitalization. Medication nonadherence is presumed to be associated with symptom exacerbations, yet how HF symptoms, medication adherence, and hospitalization/death are related remains unclear.

objectiveThe aim of this study was to explore the relationships among HF symptoms, medication adherence, and cardiac event-free survival in patients with HF.

methodsAt baseline, patient demographics, clinical data, and HF symptoms were collected in 219 patients with HF. Medication adherence was monitored using the Medication Event Monitoring System. Patients were followed for up to 3.5 years to collect hospitalization and survival data. Logistic regression and survival analyses were used for the analyses.

resultsPatients reporting dyspnea or ankle swelling were more likely to have poor medication adherence (P = .05). Poor medication adherence was associated with worse cardiac event-free survival (P = .006). In Cox regression, patients with HF symptoms had 2 times greater risk for a cardiac event than patients without HF symptoms (P = .042). Heart failure symptoms were not a significant predictor of cardiac event-free survival after entering medication adherence in the model (P = .091), indicating mediation.

conclusionsMedication adherence was associated with fewer HF symptoms and lower rates of hospitalization and death. It is important to develop interventions to improve medication adherence that may reduce HF symptoms and high hospitalization and mortality in patients with HF.

Indexed as

Medication AdherenceAgedDisease-Free SurvivalDyspneaFemaleFollow-Up StudiesHeart FailureHospitalizationHumansLogistic ModelsMaleMiddle AgedProportional Hazards ModelsProspective StudiesSocioeconomic FactorsSymptom Assessment

Identifiers

PMID28591004
PMCPMC5714687
OpenAlexW2623722747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.