Evidence map›Paper›PMID 28590587›Full record

ArticleDepression and anxiety2017

Genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and risk for treated depression after cancer diagnosis.

Nis P Suppli, Jens D Bukh, Terrie E Moffitt, Avshalom Caspi, Christoffer Johansen, Anne Tjønneland, Lars V Kessing, Susanne O Dalton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Nis P SuppliSurvivorship, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID 0000-0003-4566-6116
Jens D BukhPsychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, NC, USA.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, NC, USA.
Christoffer JohansenSurvivorship, Danish Cancer Society Research Center, Copenhagen, Denmark.
Anne TjønnelandDiet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
Lars V KessingPsychiatric Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Susanne O DaltonSurvivorship, Danish Cancer Society Research Center, Copenhagen, Denmark.
University of Copenhagen · DKDanish Cancer Society · DKDuke University · USRigshospitalet · DK

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI SCOTT M. LYNCH · 2009 to 2026
$12.2M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG032282
6 · The paper itself

Abstract

backgroundThe role of gene-environment interactions in the pathogenesis of depression is unclear. Previous studies addressed vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants; however, the importance of individual genetic variants, the environmental exposures with which they interact, and the magnitude of the risk conveyed by these interactions remain elusive.

methodsWe included 7,320 people with a first primary cancer identified in the prospective Diet, Cancer and Health study in an exposed-only cohort study. The mean age of the individuals was 68 years (5th, 95th percentiles: 58, 78) at cancer diagnosis. Using Cox regression models and cumulative incidence plots, we analyzed the associations between genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and use of antidepressants as well as hospital contact for depression after diagnosis of cancer.

resultsOverall, we observed no statistically significant associations, with nonsignificant hazard ratio estimates for use of antidepressants of 0.95-1.07.

conclusionsThis study of elderly people indicates that it is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. The mechanisms for gene-environment interactions in younger individuals are probably different, and we advise caution in extrapolating our results to early life stress. However, conclusion from the present study might be generalizable to elderly persons exposed to other stressful life events.

Indexed as

AgedAged, 80 and overBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCohort StudiesDepressive DisorderFemaleGenetic VariationHumansMaleMiddle AgedNeoplasmsReceptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport ProteinsTacrolimus Binding Protein 5Tacrolimus Binding ProteinsBDNF protein, humanBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCOMT protein, humanHTR1A protein, humanReceptor, Serotonin, 5-HT1ASerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanTacrolimus Binding Protein 5Tacrolimus Binding Proteinscancercandidate genesdepressiongene-environment interactionstressful life events

Identifiers

PMID28590587
PMCPMC5933050
OpenAlexW2622561967

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.