Evidence map›Paper›PMID 28590525›Full record

Trial reportMuscle & nerve2018

Effects of repeated abobotulinumtoxinA injections in upper limb spasticity.

Jean-Michel Gracies, Michael O'Dell, Michele Vecchio, Peter Hedera, Serdar Kocer, Monika Rudzinska-Bar, Bruce Rubin, Sofiya L Timerbaeva, Anna Lusakowska, François Constant Boyer and 4 more

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Muscle & nerve, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Composite active range of motion (CXClinical rehabilitation · 2020
    Trial
  6. Trial
  7. Trial
  8. Article
  9. Observational
  10. Observational
  11. Article
  12. Article
  13. Review
  14. Reliability of the Five Step Assessment and Its Coefficients of Impairment in Spastic Paresis.Archives of rehabilitation research and clinical translation · 2025
    Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 5 countries.

Jean-Michel GraciesEA 7377 BIOTN, Université Paris-Est Créteil, Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri Mondor, 51, avenue du Maréchal De Lattre De Tassigny, 94010, Créteil, France.
Michael O'DellDepartment of Rehabilitation Medicine, Weill Cornell Medicine, Baker Pavilion, New York, New York, USA.
Michele VecchioDepartment of U.O. Physical Medicine and Rehabilitation, Policlinico Vittorio Emanuele University Hospital, Catania, Italy.
Peter HederaDepartment of Neurology, Division of Movement Disorders, Vanderbilt University, Nashville, Tennessee, USA.
Serdar KocerCentre de Rééducation Hôpital du Jura, Porrentruy, Switzerland.
Monika Rudzinska-BarDepartment of Neurology, Faculty of Medicine, Medical University of Silesia, Katowice, Poland.
Bruce RubinDesign Neuroscience Center, Doral, Florida, USA.
Sofiya L TimerbaevaResearch Center of Neurology, Moscow, Russia.
Anna LusakowskaDepartment of Neurology, Medical University of Warsaw, Poland.
François Constant BoyerEA 3797, Unités de Médecine Physique et de Réadaptation, Hôpital Universitaire Sébastopol, Champagne Ardenne, France.
Anne-Sophie GrandoulierIpsen Innovation, Les Ulis, France.
Claire VilainIpsen Innovation, Les Ulis, France.
Philippe PicautIpsen Innovation, Les Ulis, France.
International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group
Ipsen (France) · FRAzienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · ITCornell University · USFlorida Neuroscience Center · USMedical University of Silesia · PLMedical University of Warsaw · PLResearch Center of Neurology · RUUniversité Paris-Est Créteil · FRVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe efficacy of single injections of abobotulinumtoxinA (Dysport) is established in adults with upper limb spasticity. In this study we assessed the effects of repeated injections of abobotulinumtoxinA over 1 year.

methodsPatients (n = 258, safety population) received 500 U, 1,000 U, or 1,500 U (1,500-U dose included 500-U shoulder injections) for up to 4 or 5 treatment cycles. Assessments included treatment-emergent adverse events (TEAEs), muscle tone, passive and active range of motion (X

resultsThe incidence of TEAEs decreased across cycles. Muscle tone reduction and X DISCUSSION: A favorable safety profile and continuous improvements in active movements and perceived and active function were associated with repeated abobotulinumtoxinA injections in upper limb muscles. Muscle Nerve 57: 245-254, 2018.

Indexed as

AdultAgedBotulinum Toxins, Type ADisability EvaluationDouble-Blind MethodElbowFemaleFingersHumansInjections, IntramuscularMaleMiddle AgedMuscle SpasticityMuscle TonusNeuromuscular AgentsRange of Motion, ArticularabobotulinumtoxinABotulinum Toxins, Type ANeuromuscular Agentsactive functionbotulinum toxinopen labelstroketraumatic brain injuryupper limb spasticity

Identifiers

PMID28590525
PMCPMC5811783
OpenAlexW2745937828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.