Evidence map›Paper›PMID 28590516›Full record

ArticleChemical biology & drug design2017

1,3-Bis(aryloxy)propan-2-ols as potential antileishmanial agents.

Stefânia N Lavorato, Mariana C Duarte, Daniela P Lage, Carlos A P Tavares, Eduardo A F Coelho, Ricardo J Alves

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefânia N LavoratoDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Mariana C DuarteDepartamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Daniela P LagePrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Carlos A P TavaresDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Eduardo A F CoelhoDepartamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Ricardo J AlvesDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID http://orcid.org/0000-0002-1666-4421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe herein the synthesis and antileishmanial activity of 1,3-bis(aryloxy)propan-2-ols. Five compounds (2, 3, 13, 17, and 18) exhibited an effective antileishmanial activity against stationary promastigote forms of Leishmania amazonensis (IC

Indexed as

AnimalsFemaleHumansInhibitory Concentration 50Leishmania mexicanaLeishmaniasis, CutaneousMacrophagesMice, Inbred BALB CPropanolsTrypanocidal AgentsPropanolsTrypanocidal Agentsantileishmanial activitybisaryloxyalcoholscytotoxicityLeishmania amazonensisleishmaniasis

Identifiers

PMID28590516
PMCPMC5697679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.