Evidence map›Paper›PMID 28590452›Full record

Trial reportNutrients2017

Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study.

Cesare De Gregorio, Herbert Marini, Angela Alibrandi, Antonino Di Benedetto, Alessandra Bitto, Elena Bianca Adamo, Domenica Altavilla, Concetta Irace, Giacoma Di Vieste, Diego Pancaldo and 6 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Pharmacological Effects of Genistein on Cardiovascular Diseases.Evidence-based complementary and alternative medicine : eCAM · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Cesare De GregorioDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. cdegregorio@unime.it.
Herbert MariniDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. hrmarini@unime.it.
Angela AlibrandiDepartment of Economics, Business, Environmental Science and Quantitative Methodologies, University of Messina, 98100 Messina, Italy. aalibrandi@unime.it.
Antonino Di BenedettoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. adibenedetto@unime.it.
Alessandra BittoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. abitto@unime.it.
Elena Bianca AdamoDepartment of Experimental, Specialized Medical and Surgical and Odonto-stomatological Sciences, University of Messina, 98100 Messina, Italy. elenabianca.adamo@unime.it.
Domenica AltavillaDepartment of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98100 Messina, Italy. daltavilla@unime.it.
Concetta IraceDepartment of Clinical and Experimental Medicine, University Magna Græcia, 88100 Catanzaro, Italy. irace@unicz.it.
Giacoma Di ViesteDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. jackydv@hotmail.it.
Diego PancaldoDepartment of Cardiology, SS. Annunziata Hospital, 12038 Savigliano (CN), Italy. pancaldodiego@libero.it.
Roberta GraneseDepartment of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98100 Messina, Italy. roberta.granese@unime.it.
Marco AtteritanoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. matteritano@unime.it.
Salvatore CorraoCentre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S., University of Palermo, 90127 Palermo, Italy. s.corrao@tiscali.it.
Giuseppe LicataCentre of Research for Effectiveness and Appropriateness in Medicine (C.R.E.A.M.), Di.Bi.M.I.S., University of Palermo, 90127 Palermo, Italy. licatag@unipa.it.
Francesco SquadritoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. fsquadrito@unime.it.
Vincenzo ArcoraciDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. Vincenzo.Arcoraci@unime.it.
University of Messina · ITUniversity of Palermo · ITMagna Graecia University · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genistein, a soy-derived isoflavone, may improve cardiovascular risk profile in postmenopausal women with metabolic syndrome (MetS), but few literature data on its cardiac effects in humans are available. The aim of this sub-study of a randomized double-blind case-control study was to analyze the effect on cardiac function of one-year genistein dietary supplementation in 22 post-menopausal patients with MetS. Participants received 54 mg/day of genistein (

Indexed as

Dietary SupplementsMetabolic SyndromePostmenopauseDouble-Blind MethodFemaleGenisteinHeartHumansMiddle AgedGenisteincardiac functionechocardiographygenisteinmenopausemetabolic syndrome

Identifiers

PMID28590452
PMCPMC5490563
OpenAlexW2621506349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.