Evidence map›Paper›PMID 28590310›Full record

ArticleClinical obstetrics and gynecology2017

Medical Management of Endometriosis.

Saima Rafique, Alan H Decherney

Registry-linked trialAbstract read
In one paragraph

Article in Clinical obstetrics and gynecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04527003 (A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain), which is not on this map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04527003 phase3terminatednot on this mapstarted 2020, after this paper: background citation

A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2020 to 2024Enrolled12ConditionsEndometriosis, CBD, Pelvic PainArmsCannabidiol (CBD) Extract, Norethindrone Acetate, Placebo
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Gonadotropin-releasing hormone analogues for endometriosis.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Selective oestrogen receptor modulators (SERMs) for endometriosis.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Terazosin as a Non-Hormonal Treatment for Endometriosis.International journal of molecular sciences · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Observational
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Saima Rafique*Department of Obstetrics and Gynecology, Howard University Hospital, Washington, District of Columbia †Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Alan H Decherney

Funding

Reproductive Endocrinology And Infertility Clinical Training ProgramZIEHD008737 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI HILL, MICAH · 2011 to 2025
$24.0M
Intramural NIH HHS Z99 HD999999
6 · The paper itself

Abstract

Endometriosis is a chronic medical condition that affects around 6% to 10% of reproductive age women. Pelvic pain, dysmenorrhea, and infertility are the most common presenting symptoms. The disease is characterized by estrogen-dependent growth of the endometrial glands and stroma outside the endometrial cavity. The diagnosis requires a high degree of suspicion and can be only confirmed on histopathology. Treatment includes medical and surgical options. Both hormonal and nonhormonal medical options are available and are tried at first with a goal to control pain and stop the growth of the endometriotic lesions. Nonsteroidal anti-inflammatory drugs, oral contraceptive pills, gonadotropin-releasing hormone (GnRH) agonists, aromatase inhibitors are some of the commonly used medications. With more research on the molecular and biochemical aspects of endometriosis, newer targets of therapy are being developed like selective progesterone receptor modulators, antiangiogenic factors and immunomodulators. In women who do not respond to medical therapy or have severe symptoms, surgical excision of the endometrial lesions and adhesions is often helpful and offers confirmatory diagnosis by histopathology.

Indexed as

Angiogenesis InhibitorsAnti-Inflammatory Agents, Non-SteroidalCombined Modality TherapyDysmenorrheaEndometriosisEndometriumFemaleGonadotropin-Releasing HormoneHormonesHumansPain ManagementPelvic PainTreatment OutcomeAngiogenesis InhibitorsAnti-Inflammatory Agents, Non-SteroidalGonadotropin-Releasing HormoneHormones

Identifiers

PMID28590310
PMCPMC5794019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.