ArticleAnesthesiology2017
A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits.
Article in Anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- MERTK-related engulfment of norepinephrinergic neuronal presynaptic membrane by astrocytes following acute TBI and potentiation effect of peripheral nerve modulation.Annals of medicine · 2026Article
- μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice.The Journal of physiology · 2026Article
- Partially countering the physiological effects of fentanyl with naloxone or d-cysteine ethyl ester in adult goats.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- High proportions of respiratory and non-respiratory modulated pre-Bötzinger complex neurons receive monosynaptic inputs from the pontine respiratory group in rabbit.Respiratory physiology & neurobiology · 2026Article
- The role of carotid bodies in opioid-induced respiratory depression.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Single-nucleus and spatial signatures of the brainstem in normal brain and mild traumatic brain injury in male mice.Nature communications · 2025Article
- Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy.Pharmacology & therapeutics · 2025Review
- Etorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol.Conservation physiology · 2025Article
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.Nature communications · 2024Article
- Involvement of the parabrachial nucleus in emergence from general anesthesia.Frontiers in neuroscience · 2024Review
- The Modulation by Anesthetics and Analgesics of Respiratory Rhythm in the Nervous System.Current neuropharmacology · 2024Review
- A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.bioRxiv : the preprint server for biology · 2023Article
- Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms.eLife · 2023Article
- Article
- Review
- Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area.Frontiers in neuroscience · 2023Review
- Changes in pontine and preBötzinger/Bötzinger complex neuronal activity during remifentanil-induced respiratory depression in decerebrate dogs.Frontiers in physiology · 2023Article
- Mechanisms of opioid-induced respiratory depression.Archives of toxicology · 2022Review
- Contribution of the caudal medullary raphe to opioid induced respiratory depression.Respiratory physiology & neurobiology · 2022Article
- Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kölliker-Fuse Complex and Pre-Bötzinger Complex.Anesthesiology · 2021Article
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
backgroundThe efficacy of opioid administration to reduce postoperative pain is limited by respiratory depression. We investigated whether clinically relevant opioid concentrations altered the respiratory pattern in the parabrachial nucleus, a pontine region contributing to respiratory pattern generation, and compared these effects with a medullary respiratory site, the pre-Bötzinger complex.
methodsStudies were performed in 40 young and 55 adult artificially ventilated, decerebrate rabbits. We identified an area in the parabrachial nucleus where α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid microinjections elicited tachypnea. Two protocols were performed in separate sets of animals. First, bilateral microinjections of the μ-opioid receptor agonist [D-Ala, N-MePhe, Gly-ol]-enkephalin (100 μM) into the "tachypneic area" determined the effect of maximal μ-opioid receptor activation. Second, respiratory rate was decreased with continuous IV infusions of remifentanil. The opioid antagonist naloxone (1 mM) was then microinjected bilaterally into the "tachypneic area" of the parabrachial nucleus to determine whether the respiratory rate depression could be locally reversed.
resultsAverage respiratory rate was 27 ± 10 breaths/min. First, [D-Ala, N-MePhe, Gly-ol]-enkephalin injections decreased respiratory rate by 62 ± 20% in young and 45 ± 26% in adult rabbits (both P < 0.001). Second, during IV remifentanil infusion, bilateral naloxone injections into the "tachypneic area" of the parabrachial nucleus reversed respiratory rate depression from 55 ± 9% to 20 ± 14% in young and from 46 ± 20% to 18 ± 27% in adult rabbits (both P < 0.001). The effects of bilateral [D-Ala, N-MePhe, Gly-ol]-enkephalin injection and IV remifentanil on respiratory phase duration in the "tachypneic area" of the parabrachial nucleus was significantly different from the pre-Bötzinger complex.
conclusionsThe "tachypneic area" of the parabrachial nucleus is highly sensitive to μ-opioid receptor activation and mediates part of the respiratory rate depression by clinically relevant administration of opioids.
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