ArticleeLife2017
Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Using Electroencephalography to Assess Coma Etiology in Children with Retinopathy-Negative Cerebral Malaria.The American journal of tropical medicine and hygiene · 2025Article
- Re-evaluating malarial retinopathy to improve its diagnostic accuracy in paediatric cerebral malaria: A retrospective study.PLoS medicine · 2025Article
- The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria.Science advances · 2024Article
- Clinical aspects of malarial retinopathy: a critical review.Pathogens and global health · 2023Review
- Using Malarial Retinopathy to Improve the Diagnosis of Pediatric Cerebral Malaria.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Pediatric Cerebral Malaria.Current tropical medicine reports · 2021Article
- Retinopathy-Positive Cerebral Malaria Is Associated With Greater Inflammation, Blood-Brain Barrier Breakdown, and Neuronal Damage Than Retinopathy-Negative Cerebral Malaria.Journal of the Pediatric Infectious Diseases Society · 2020Article
- Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria.Blood advances · 2020Article
- Central Nervous System Virus Infection in African Children with Cerebral Malaria.The American journal of tropical medicine and hygiene · 2020Article
- Plasma cell-free DNA predicts pediatric cerebral malaria severity.JCI insight · 2020Article
- EVIDENCE FACTORS IN A CASE-CONTROL STUDY WITH APPLICATION TO THE EFFECT OF FLEXIBLE SIGMOIDOSCOPY SCREENING ON COLORECTAL CANCER.The annals of applied statistics · 2020Article
- Desperately Seeking Therapies for Cerebral Malaria.Journal of immunology (Baltimore, Md. : 1950) · 2020Review
- MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.Microbiology and molecular biology reviews : MMBR · 2018Review
- Do we know enough to find an adjunctive therapy for cerebral malaria in African children?F1000Research · 2017Review
- Automated malarial retinopathy detection using transfer learning and multi-camera retinal images.Biocybernetics and biomedical engineeringArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Cerebral malaria (CM) can be classified as retinopathy-positive or retinopathy-negative, based on the presence or absence of characteristic retinal features. While malaria parasites are considered central to the pathogenesis of retinopathy-positive CM, their contribution to retinopathy-negative CM is largely unknown. One theory is that malaria parasites are innocent bystanders in retinopathy-negative CM and the etiology of the coma is entirely non-malarial. Because hospitals in malaria-endemic areas often lack diagnostic facilities to identify non-malarial causes of coma, it has not been possible to evaluate the contribution of malaria infection to retinopathy-negative CM. To overcome this barrier, we studied a natural experiment involving genetically inherited traits, and find evidence that malaria parasitemia does contribute to the pathogenesis of retinopathy-negative CM. A lower bound for the fraction of retinopathy-negative CM that would be prevented if malaria parasitemia were to be eliminated is estimated to be 0.93 (95% confidence interval: 0.68, 1).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.