ArticleNature communications2017
Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- TRACR: an anterograde transneuronal tracing system for genetic access across synapses and longitudinal circuit analysis.bioRxiv : the preprint server for biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways.The Journal of general physiology · 2024Article
- Asymmetric connections with starburst amacrine cells underlie the upward motion selectivity of J-type retinal ganglion cells.PLoS biology · 2023Article
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- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
- Rapid multi-directed cholinergic transmission in the central nervous system.Nature communications · 2021Article
- Article
- Cross-Talk of Low-Level Sensory and High-Level Cognitive Processing: Development, Mechanisms, and Relevance for Cross-Modal Abilities of the Brain.Frontiers in neurorobotics · 2020Review
- Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry.Frontiers in cellular neuroscience · 2020Article
- AMIGO2 Scales Dendrite Arbors in the Retina.Cell reports · 2019Article
- Neural mechanisms of contextual modulation in the retinal direction selective circuit.Nature communications · 2019Article
- Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses.eLife · 2019Article
- Stimulus-dependent engagement of neural mechanisms for reliable motion detection in the mouse retina.Journal of neurophysiology · 2018Review
- Cholinergic excitation complements glutamate in coding visual information in retinal ganglion cells.The Journal of physiology · 2018Article
- Heterocellular Coupling Between Amacrine Cells and Ganglion Cells.Frontiers in neural circuits · 2018Article
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- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retina processes visual images to compute features such as the direction of image motion. Starburst amacrine cells (SACs), axonless feed-forward interneurons, are essential components of the retinal direction-selective circuitry. Recent work has highlighted that SAC-mediated dendro-dendritic inhibition controls the action potential output of direction-selective ganglion cells (DSGCs) by vetoing dendritic spike initiation. However, SACs co-release GABA and the excitatory neurotransmitter acetylcholine at dendritic sites. Here we use direct dendritic recordings to show that preferred direction light stimuli evoke SAC-mediated acetylcholine release, which powerfully controls the stimulus sensitivity, receptive field size and action potential output of ON-DSGCs by acting as an excitatory drive for the initiation of dendritic spikes. Consistent with this, paired recordings reveal that the activation of single ON-SACs drove dendritic spike generation, because of predominate cholinergic excitation received on the preferred side of ON-DSGCs. Thus, dendro-dendritic release of neurotransmitters from SACs bi-directionally gate dendritic spike initiation to control the directionally selective action potential output of retinal ganglion cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.