Evidence map›Paper›PMID 28589753›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Evaluating the gray and white matter energy budgets of human brain function.

Yuguo Yu, Peter Herman, Douglas L Rothman, Divyansh Agarwal, Fahmeed Hyder

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.

  1. Pooled it
  2. Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  7. Review
  8. Review
  9. Inorganic phosphate and the rapid mobilization of metabolic energy in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Mitochondrial CaBiomolecules · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. HyperpolarizedImaging neuroscience (Cambridge, Mass.) · 2026
    Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yuguo Yu1 School of Life Science and the Collaborative Innovation Center for Brain Science, the Center for Computational Systems Biology, Fudan University, Shanghai, China.
Peter Herman2 Department of Radiology and Biomedical Imaging Yale University, New Haven, CT, USA.
Douglas L Rothman2 Department of Radiology and Biomedical Imaging Yale University, New Haven, CT, USA.
Divyansh Agarwal3 Magnetic Resonance Research Center, Yale University, New Haven, CT, USA.
Fahmeed Hyder2 Department of Radiology and Biomedical Imaging Yale University, New Haven, CT, USA.
Yale University · USFudan University · CNResonance Research (United States) · US

Funding

NeurophysiologicP30NS052519 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2007 to 2017
$6.7M
Energetics of Neuronal Populations by fMRIR01MH067528 · NIMH · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2002 to 2021
$5.9M
13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1M
Validation of GABA MRS as a Biomarker of InhibitionR01MH109159 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, ROTHMAN, DOUGLAS LYLE · 2016 to 2019
$1.7M
MRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959k
Assessing the Relationship between Cortical Oxidative Metabolism and Working Memory Deficits Under NMDA Receptor BlockadeR21MH110862 · NIMH · YALE UNIVERSITY · PI DRIESEN, NAOMI R, HYDER, DEWAN SYED FAHMEED · 2017 to 2018
$404k
NIMH NIH HHS R01 MH067528NIMH NIH HHS R01 MH109159NIMH NIH HHS R21 MH110862NINDS NIH HHS P30 NS052519NINDS NIH HHS R01 NS087568NINDS NIH HHS R01 NS100106
6 · The paper itself

Abstract

The insatiable appetite for energy to support human brain function is mainly supplied by glucose oxidation (CMR

Indexed as

Energy MetabolismAnimalsBrainGlucoseGlycolysisGray MatterHumansOxidation-ReductionRatsWakefulnessWhite MatterGlucoseAerobic glycolysisastrocyteelectroencephalographyglutamatelactatespiking rate

Identifiers

PMID28589753
PMCPMC6092772
OpenAlexW2621969480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.