Evidence map›Paper›PMID 28589709›Full record

ArticleGenesis (New York, N.Y. : 2000)2017

Generation of Nkx2-5/CreER transgenic mice for inducible Cre expression in developing hearts.

Sara Ranjbarvaziri, Shuin Park, Ngoc B Nguyen, William B Gilmore, Peng Zhao, Reza Ardehali

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genesis (New York, N.Y. : 2000), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Hypoxia regulate developmental coronary angiogenesis potentially through VEGF-R2- and SOX17-mediated signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  2. Profiling proliferative cells and their progeny in damaged murine hearts.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sara RanjbarvaziriDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.ORCID 0000-0003-0826-5487
Shuin ParkDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.
Ngoc B NguyenDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.
William B GilmoreDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.
Peng ZhaoDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.
Reza ArdehaliDivision of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, 90095.
University of California, Los Angeles · US

Funding

Vascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4M
Exploring heterogeneity of cardiac fibroblasts to reverse fibrosisDP2HL127728 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDEHALI, REZA · 2014 to 2014
$2.3M
NHLBI NIH HHS DP2 HL127728NHLBI NIH HHS T32 HL069766
6 · The paper itself

Abstract

Nkx2-5 is a homeobox-containing transcriptional regulator that serves as one of the earliest markers of cardiac lineage commitment. To study the role of Nkx2-5-expressing progenitors at specific time points in cardiac development, we have generated a novel and inducible NKX2-5 mouse line by knocking in a CreER cassette into the Nkx2-5 genomic locus, while preserving the endogenous Nkx2-5 gene to avoid haploinsufficiency. We evaluated the specificity and efficiency of CreER activity after 4-OHT injection by crossing Nkx2-5

Indexed as

AnimalsCell LineageGene TargetingGenetic EngineeringHeartHomeobox Protein Nkx-2.5IntegrasesLuminescent ProteinsMiceMyocytes, CardiacTransgenesCre recombinasefluorescent protein 583Homeobox Protein Nkx-2.5IntegrasesLuminescent ProteinsNkx2-5 protein, mousecardiac developmentinducible CreER recombinaseNkx2-5

Identifiers

PMID28589709
PMCPMC5568924
OpenAlexW2622543645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.