Evidence map›Paper›PMID 28589541›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2017

Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls.

Hanneke van Ewijk, Janita Bralten, Esther D A van Duin, Marina Hakobjan, Jan K Buitelaar, Dirk J Heslenfeld, Pieter J Hoekstra, Catharina Hartman, Martine Hoogman, Jaap Oosterlaan and 1 more

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In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Hanneke van EwijkSection Clinical Neuropsychology, Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, The Netherlands.
Janita BraltenDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Esther D A van DuinDepartment of Psychiatry and Psychology, Maastricht University, Maastricht, The Netherlands.
Marina HakobjanDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Jan K BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-8288-7757
Dirk J HeslenfeldSection Clinical Neuropsychology, Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, The Netherlands.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Catharina HartmanDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Martine HoogmanDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Jaap OosterlaanSection Clinical Neuropsychology, Department of Clinical, Neuro- and Developmental Psychology, Faculty of Behavioural and Movement Sciences, VU Amsterdam, Amsterdam, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLAmsterdam Neuroscience · NLUniversity Medical Center Groningen · NLMaastricht University · NL

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Analysis of an ADHD Whole Genome Association ScanR01MH081803 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2007 to 2007
$157k
NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH081803
6 · The paper itself

Abstract

backgroundThe nitric oxide synthase gene (NOS1) exon 1f (ex1f) VNTR is a known genetic risk factor for Attention-Deficit/Hyperactivity Disorder (ADHD), particularly in females. NOS1 plays an important role in neurite outgrowth and may thus influence brain development, specifically white matter (WM) microstructure, which is known to be altered in ADHD. The current study aimed to investigate whether NOS1 is associated with WM microstructure in (female) individuals with and without ADHD.

methodsDiffusion Tensor Imaging (DTI) scans were collected from 187 participants with ADHD (33% female) and 103 controls (50% female), aged 8-26 years, and NOS1-ex1f VNTR genotype was determined. Whole-brain analyses were conducted for fractional anisotropy (FA) and mean diffusivity (MD) to examine associations between NOS1 and WM microstructure, including possible interactions with gender and diagnosis.

resultsConsistent with previous literature, NOS1-ex1f was associated with total ADHD and hyperactivity-impulsivity symptoms, but not inattention; this effect was independent of gender. NOS1-ex1f was also associated with MD values in several major WM tracts in females, but not males. In females, homozygosity for the short allele was linked to higher MD values than carriership of the long allele. MD values in these regions did not correlate with ADHD symptoms. Results were similar for participants with and without ADHD.

conclusionsNOS1-ex1f VNTR is associated with WM microstructure in females in a large sample of participants with ADHD and healthy controls. Whether this association is part of a neurodevelopmental pathway from NOS1 to ADHD symptoms should be further investigated in future studies.

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityChildDiffusion Tensor ImagingFemaleGenotypeHumansMaleNitric Oxide Synthase Type ISex CharacteristicsWhite MatterYoung AdultNitric Oxide Synthase Type INOS1 protein, humanattention-deficit/hyperactivity disorderdiffusion tensor imagingimaging geneticsNOS1

Identifiers

PMID28589541
PMCPMC5513773
OpenAlexW2623611383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.