Evidence map›Paper›PMID 28589429›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2017

Influence of ovarian cancer type I and type II microenvironment on the phenotype and function of monocyte-derived dendritic cells.

J Surówka, I Wertel, K Okła, W Bednarek, R Tarkowski, J Kotarski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

J SurówkaI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland. justyna.surowka@gmail.com.
I WertelI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland.
K OkłaI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland.
W BednarekI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland.
R TarkowskiI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland.
J KotarskiI Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Al. Racławickie 1, 20-059, Lublin, Poland.
Medical University of Lublin · PL

Funding

Uniwersytet Medyczny w Lublinie MNsd129
6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the influence of ovarian cancer cell lysates isolated from type I or type II ovarian cancer (OC) on the phenotype of monocyte-derived dendritic cells (Mo-DCs) and the cytokine profile. We also determined whether the Mo-DCs and tumor microenvironment, reflected by peritoneal fluid (PF) from type I or II ovarian cancer, could promote regulatory T cell (Tregs) differentiation from naive CD4

resultsOur results show a significant role of the ovarian cancer microenvironment reflected by PF from type I or II OC in the inhibition of the DC differentiation process. Interestingly, the percentage of cells co-expressing CD45 and CD14 antigens in the cultures stimulated with PF from both type I and type II OC was higher than in the control. Furthermore, the percentage of cells expressing CD1a, i.e., a marker of immature DCs, was significantly reduced in the cultures stimulated with PF from type I and type II OC. The results obtained show that ovarian cancer type II lysates induce differentiation of monocytes into macrophage-like cells with a CD1a

conclusionsWe demonstrate that each type of ovarian cancer can induce a unique phenotype of DCs and differentiation of Tregs, both associated with immune-suppressive function, which may be an obstacle while developing effective anticancer dendritic cell vaccination.

Indexed as

Cell DifferentiationTumor MicroenvironmentAdenocarcinoma, MucinousAdultAgedAged, 80 and overAntigens, CDCystadenocarcinoma, SerousDendritic CellsEndometrial NeoplasmsFemaleFollow-Up StudiesHumansInterleukin-10Middle AgedMonocytesAntigens, CDIL10 protein, humanInterleukin-10Cell culturesDendritic cellsOvarian cancerPeritoneal fluidRegulatory T cells

Identifiers

PMID28589429
PMCPMC5700226
OpenAlexW2623450661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.