Evidence map›Paper›PMID 28589419›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Breastfeeding as the sole source of milk for 6 months and adolescent bone mineral density.

E Blanco, R Burrows, M Reyes, B Lozoff, S Gahagan, C Albala

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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0cells of the map it votes in
7citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

E BlancoDepartment of Pediatrics, UC San Diego, 9500 Gilman Drive, MC 0927, La Jolla, CA, 92093-0927, USA. esblanco@ucsd.edu.
R BurrowsPublic Health Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Avenida El Líbano 5524, Macul, Santiago de Chile, Chile.
M ReyesPublic Health Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Avenida El Líbano 5524, Macul, Santiago de Chile, Chile.
B LozoffCenter for Human Growth and Development, University of Michigan, 300 North Ingalls, Ann Arbor, MI, 48109-5406, USA.
S GahaganDepartment of Pediatrics, UC San Diego, 9500 Gilman Drive, MC 0927, La Jolla, CA, 92093-0927, USA.
C AlbalaPublic Health Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Avenida El Líbano 5524, Macul, Santiago de Chile, Chile.

Funding

NEUROMATURATION DELAYS IN IRON DEFICIENT ANEMIC INFANTSR01HD033487 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA, LOZOFF, BETSY · 1997 to 2016
$8.8M
Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular RiskR01HL088530 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAHAGAN, SHEILA · 2008 to 2017
$5.0M
NHLBI NIH HHS R01 HL088530NICHD NIH HHS R01 HD033487
6 · The paper itself

Abstract

Little is known regarding the relationship between early life factors and bone mineral density (BMD). We found a positive association between breastfeeding for at least 6 months, without formula supplementation, and whole body adolescent BMD z-score.

introductionThe aim of the study is to assess the role of breastfeeding BF on adolescent bone mineral density (BMD) in a cohort prospectively followed since infancy.

methodsWe studied 679 participants from an infancy iron deficiency anemia preventive trial in Santiago, Chile, followed to adolescence. Breast and bottle feeding were ascertained weekly from 4 to 12 months. At 16 years, whole body BMD was assessed by DEXA. Using linear regression, we evaluated associations between BF duration and BF as the sole source of milk and adolescent BMD z-score, adjusting for possible infancy, adolescent, and background confounders.

resultsMean birth weight and length were 3.5 (0.3) kg and 50.7 (1.6) cm. For at least 6 months, BF was the sole source of milk for 26.3% and with supplementation for 36.7%. For 37%, BF was provided for less than 6 months. Mean 16-year BMD z-score was 0.25 (1.0). Covariates included male sex, birth length, and gestational age. BF as the sole source of milk ≥6 months, compared to BF < 6 months, was associated with higher adolescent BMD z-score adjusting for covariates (β = 0.29, p < 0.05). Mixed BF was not significantly related to adolescent BMD z-score (β = 0.06, p = 0.47). For every 30 days of BF as the sole source of milk, adolescent BMD z-score increased by 0.03 (p = 0.01).

conclusionBF without formula supplementation for at least 6 months was associated with higher adolescent BMD z-score and a suggestive trend in the same direction for BMD suggests that exclusivity and duration of BF may play a role in adolescent bone health.

Indexed as

Breast FeedingAbsorptiometry, PhotonAdolescentAge FactorsAgingBirth WeightBody HeightBone DensityFemaleFollow-Up StudiesGestational AgeHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaMaleBone healthDevelopmental origins of diseaseLactationOsteoporosis

Identifiers

PMID28589419
PMCPMC5840801

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.