ArticleJournal of bone and mineral metabolism2018
Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.
Article in Journal of bone and mineral metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Estrogen loss activates memory T-cells to compromise bone integrity through distinct cortical compartments in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Quantitative image analysis of the extracellular matrix of esophageal squamous cell carcinoma and high grade dysplasia via two-photon microscopy.Scientific reports · 2025Article
- Landscape of Well-Coordinated Fracture Healing in a Mouse Model Using Molecular and Cellular Analysis.International journal of molecular sciences · 2023Article
- Design and clinical application of injectable hydrogels for musculoskeletal therapy.Bioengineering & translational medicine · 2022Review
- Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae.International journal of molecular sciences · 2021Article
- Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis.International journal of molecular sciences · 2021Article
- Podosome-Driven Defect Development in Lamellar Bone under the Conditions of Senile Osteoporosis Observed at the Nanometer Scale.ACS biomaterials science & engineering · 2021Article
- Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.Bone · 2019Article
- Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometry.Journal of the Royal Society, Interface · 2019Article
- First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple-helix nanofibril mineralization.Scientific reports · 2018Article
- Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model.Journal of musculoskeletal & neuronal interactions · 2018Article
- Early osteoimmunomodulatory effects of magnesium-calcium-zinc alloys.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlooked. The current study considered the spine matrix properties of ovariectomized rats (OVX) against control rats (Sham) at 16 months of age. Diseased bone showed less compact structure with inhomogeneous distribution of type 1 collagen (Col1) and changes in osteocyte morphology. Intriguingly, demineralization patches were noticed in the vicinity of blood vessels in the OVX spine. The organic matrix structure was investigated using computational segmentation of collagen fibril properties. In contrast to the aged bone, diseased bone showed longer fibrils and smaller orientation angles. The study shows the potential of quantifying transmission electron microscopy images to predict the mechanical properties of bone tissue.
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Registered trials
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