Evidence map›Paper›PMID 28589382›Full record

ArticleJournal of endocrinological investigation2017

Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features.

M P Yavropoulou, G Panagiotou, K Topouridou, G Karayannopoulou, T Koletsa, T Zarampoukas, A Goropoulos, E Chatzaki, J G Yovos, K Pazaitou-Panayiotou

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In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Vitamin D-Related Genes and Thyroid Cancer-A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Vitamin DInternational journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

M P YavropoulouDivision of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
G PanagiotouDepartment of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, 2 Al Simeonidi Str, 54007, Thessaloniki, Greece.
K TopouridouDivision of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
G KarayannopoulouPathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
T KoletsaPathology Department, Faculty of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
T ZarampoukasHistopathology Laboratory, Istodierevnitiki S.A, Thessaloniki, Greece.
A GoropoulosDepartment of Endocrine Surgery, Saint Luke's General Hospital, Thessaloniki, Greece.
E ChatzakiLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
J G YovosDivision of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
K Pazaitou-PanayiotouDepartment of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, 2 Al Simeonidi Str, 54007, Thessaloniki, Greece. kpazaitoupanayiotou@gmail.com.
AHEPA University Hospital · GRAristotle University of Thessaloniki · GRTheageneio General Hospital · GRDemocritus University of Thrace · GRHellenic Agency for Local Development and Local Government · GRSt. Luke's Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVitamin D receptor (VDR) and progesterone receptor (PR) expression has been described in papillary thyroid carcinoma (PTC) but data regarding association with tumor histological characteristics and localization of the protein expression are scarce. MATERIALS AND

methodsFormalin-fixed, paraffin-embedded specimens from 45 patients with PTC (cases) were retrieved and tumor histological data were recorded. We analyzed gene and protein expression of VDR and PR and gene expression of vitamin D-inactivating 24-hyroxylase (CYP24A1) and the activating 1-alpha-hydroxylase (CYP27B1) enzymes in follicular cancer cells and the adjacent non-neoplastic thyroid tissue (NNTT).

resultsVDR mRNA and protein expression was higher in PTC compared with NNTT (p < 0.05). The protein was globally localized in the cytoplasm and cell membranes of the neoplastic cells in all cases, with differences in intensity. Cytoplasmic positivity was stronger in the majority of cases. Membranous positivity was also evident in cases, whereas in NNTT was generally weak and in a low percentage of the cells. Expression of CYP 24A1, but not CYP27B1, was increased in approximately all PTC specimens and was associated with lymph node metastasis and extrathyroidal extension. PR mRNA was increased in 34% and protein expression was present in 57% of cases, and none of NNTT. PR, but not VDR, mRNA expression was significantly associated with the tumor size (r = 0.645, p = 0.007).

conclusionsWe provide evidence for the expression pattern of VDR, PR and CYP24A1 in the progression of PTC. Rapid anti-tumor responses of vitamin D in PTC may be blocked due to inactivation of local vitamin D metabolism.

Indexed as

25-Hydroxyvitamin D3 1-alpha-HydroxylaseAdultAgedBiomarkers, TumorCarcinoma, PapillaryCase-Control StudiesFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedPrognosisReceptors, CalcitriolReceptors, ProgesteroneRNA, Messenger25-Hydroxyvitamin D3 1-alpha-HydroxylaseBiomarkers, TumorCYP24A1 protein, humanCYP27B1 protein, humanReceptors, CalcitriolReceptors, ProgesteroneRNA, MessengerVDR protein, humanVitamin D3 24-HydroxylaseCYP24A1CYP27B1HistologyImmunohistochemistryNon-genomic actionNuclear receptor

Identifiers

PMID28589382
OpenAlexW2622324459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.