Evidence map›Paper›PMID 28589234›Full record

Trial reportParasitology research2017

Action of nitromezuril against Eimeria tenella with clinically anticoccidial indices and histopathology.

Rufeng She, Chenzhong Fei, Huiya Chen, Xiaoyang Wang, Mi Wang, Keyu Zhang, Lifang Zhang, Chunmei Wang, Yingchun Liu, Wenli Zheng and 1 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Parasitology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rufeng SheKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Chenzhong FeiKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China. aries@shvri.ac.cn.ORCID http://orcid.org/0000-0002-2345-6188
Huiya ChenKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Xiaoyang WangKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Mi WangKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Keyu ZhangKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Lifang ZhangKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Chunmei WangKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Yingchun LiuKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Wenli ZhengKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China.
Feiqun XueKey Laboratory for Veterinary Chemical Drugs and Pharmaceutics, Ministry of Agriculture, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No.518 Ziyue Rd, Minhang Dist, 200241, Shanghai, People's Republic of China. fqxue@shvri.ac.cn.
Shanghai Veterinary Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitromezuril is a novel triazine compound for preventing coccidiosis in broiler chickens. A single treatment of chickens inoculated with Eimeria tenella during the endogenous phase were used to evaluate the developmental stages of action of nitromezuril by clinically anticoccidial indices and histopathology. Results showed that a single dose of nitromezuril at 5 mg/kg b.w. during 56 to 80 h post-inoculation can most effectively prevent weight loss and reduce both oocyst shedding and caecal lesions. The anticoccidial index reached the level of middle efficacy. Histological examinations indicated that administration of nitromezuril during 44 to 104 h after infection significantly reduced the merozoite population and the pathological damage to the caecum. Nitromezuril treatment could disturb the process of schizonts division into schizoites and produce abnormal schizonts. Overall, nitromezuril may exert its effects during the entire endogenous stage of the parasites but the schizogony stages were intrinsically more vulnerable. Nitromezuril is a potential novel anticoccidial agent suitable for further development.

Indexed as

ChickensAnimalsCecumCoccidiosisCoccidiostatsEimeria tenellaMerozoitesOocystsPoultry DiseasesSchizontsTriazines2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dioneCoccidiostatsTriazinesAnticoccidial indicesCoccidiostatsEimeria tenellaHistopathologyNitromezuril

Identifiers

PMID28589234
OpenAlexW2623311648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.