Evidence map›Paper›PMID 28589222›Full record

ArticleEuropean child & adolescent psychiatry2018

Prescribing of medication for attention deficit hyperactivity disorder among young people in the Clinical Practice Research Datalink 2005-2013: analysis of time to cessation.

Tamsin Newlove-Delgado, Tamsin J Ford, William Hamilton, Ken Stein, Obioha C Ukoumunne

Abstract readHistorical Article
In one paragraph

Article in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tamsin Newlove-DelgadoUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK. t.newlove-delgado@exeter.ac.uk.
Tamsin J FordUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
William HamiltonUniversity of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
Ken SteinNIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.
Obioha C UkoumunneNIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK.

Funding

Department of Health 10/140/02Department of Health DRF-2012-05-221National Institute for Health Research DRF-2012-05-221
6 · The paper itself

Abstract

The aim of this study was to examine the time to cessation of ADHD medication amongst young people with ADHD aged 16 in the period 2005-2013. Previous studies of prescribing in primary care reported high rates of medication cessation amongst 16 and 17 year olds with ADHD. The examination of trends since the introduction of new NICE guidance in 2008 will support service planning and improvement of outcomes over the vulnerable transition period from child to adult services. We used primary care records from the Clinical Practice Research Datalink and identified cases prescribed ADHD medication at the time of their 16th birthday during the study period. The outcome was time to medication cessation from the age of 16. Cessation of medication was defined as occurring at the beginning of a gap of over 6 months in prescriptions. 1620 cases were included. The median time to cessation was 1.51 years (95% CI 1.42-1.67).The estimated probability of remaining on medication was 0.63 (95% CI 0.61-0.65) at age 17 (i.e., at 1 year) and 0.41 (95% CI 0.39-0.43) at age 18. Young people with ADHD remain at high risk of cessation of medication during the transition from child to adult services. Despite the restriction that only primary care prescribing data were available, the results suggest continuing disparity between expected levels of symptom persistence and continuation of medication.

Indexed as

AdolescentAdultAttention Deficit Disorder with HyperactivityFemaleHistory, 21st CenturyHumansMalePsychopharmacologyTime FactorsYoung AdultADHDDiscontinuationPrescribingPsychopharmacologyTransition

Identifiers

PMID28589222
PMCPMC5799339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.