Evidence map›Paper›PMID 28589100›Full record

ArticleFrontiers in cellular and infection microbiology2017

MicroRNA-21 Limits Uptake of

Daniel G W Johnston, Jay Kearney, Zbigniew Zasłona, Michelle A Williams, Luke A J O'Neill, Sinéad C Corr

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. The Regulatory Mechanisms of Treponema pallidum Enolase on Macrophages: From Enzymatic Activity to Signal Transduction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Salmon nasal cartilage proteoglycan up-regulatesCurrent research in microbial sciences · 2025
    Article
  5. Article
  6. Macrophage variants in laboratory research: most are well done, but some are RAW.Frontiers in cellular and infection microbiology · 2024
    Review
  7. Article
  8. Article
  9. Analysis of miRNA Expression Profiling ofInternational journal of molecular sciences · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Proteome Profiling of PMJ2-R and Primary Peritoneal Macrophages.International journal of molecular sciences · 2021
    Article
  16. PDCD4-mediated downregulation ofCentral-European journal of immunology · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel G W JohnstonSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinDublin, Ireland.
Jay KearneySchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinDublin, Ireland.
Zbigniew ZasłonaSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinDublin, Ireland.
Michelle A WilliamsDepartment of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College DublinDublin, Ireland.
Luke A J O'NeillSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College DublinDublin, Ireland.
Sinéad C CorrDepartment of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College DublinDublin, Ireland.
Trinity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of infections. We investigated the influence of miR-21 on macrophage responses during infection with

Indexed as

AnimalsCytochalasin DCytokinesCytoplasmGene ExpressionInterleukin-10Interleukin-6LipopolysaccharidesListeria monocytogenesListeriosisMacrophagesMiceMice, Inbred C57BLMicroRNAsMyristoylated Alanine-Rich C Kinase SubstrateNitric OxideCytochalasin DCytokinesInterleukin-10Interleukin-6LipopolysaccharidesMarcks protein, mouseMicroRNAsMIRN21 microRNA, mouseMyristoylated Alanine-Rich C Kinase SubstrateNitric Oxiderho GTP-Binding ProteinsTumor Necrosis Factor-alphaListeriamacrophageMARCKSmicroRNAmiR-21phagocytosis

Identifiers

PMID28589100
PMCPMC5440467
OpenAlexW2618211952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.