ArticleEuropean thyroid journal2017
Lymph Node Metastases in Papillary and Medullary Thyroid Carcinoma Are Independent of Intratumoral Lymphatic Vessel Density.
Article in European thyroid journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Lymphatic vessel density as a prognostic indicator in Asian NSCLC patients: a meta-analysis.BMC pulmonary medicine · 2018Pooled it
- A clinically practical machine learning nomogram for preoperative CLNM prediction in PTMC: tumor-capsule distance and D2-40 evidence.Frontiers in oncology · 2026Article
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- Intranodular and perinodular ultrasound radiomics distinguishes benign and malignant thyroid nodules: a multicenter study.Gland surgery · 2024Article
- Machine Vision-Detected Peritumoral Lymphocytic Aggregates Are Associated With Disease-Free Survival in Patients With Papillary Thyroid Carcinoma.Laboratory investigation; a journal of technical methods and pathology · 2024Article
- Advances in the Diagnosis and Treatment of Follicular Thyroid Carcinoma: A Comprehensive Review.Cureus · 2024Review
- Occult Thyroid Carcinoma with Cervical Lymph Node Metastasis: A Rare Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- [Contrast-enhanced ultrasonography with intra-glandular contrast injection can improve the diagnostic accuracy of central compartment lymph node metastasis of thyroid cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Is Encapsulated Medullary Thyroid Carcinoma Associated With a Better Prognosis? A Case Series and a Review of the Literature.Frontiers in endocrinology · 2022Review
- Article
- Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.Biomedicines · 2020Article
- Sentinel Lymph Node Biopsy in Thyroid Cancer.World journal of surgery · 2020Article
- Angiogenesis and Lymphangiogenesis in the Adrenocortical Tumors.Pathology oncology research : POR · 2018Article
- The Prognostic Role of Lymphatic Vessel Density in Papillary Thyroid Carcinoma: A Systematic Review and Meta-analysis.Cancer diagnosis & prognosisReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood and lymph vessel invasion are well-recognized markers of tumor aggressiveness, as these are the routes that lead to metastases. Thyroid tumors, depending on the histological variant, tend to have distinctive biological behaviors and use different vascular routes to metastasize, yet the mechanisms underlying the metastatic process are still poorly understood.
objectivesThe aim of this study was to assess how the lymph vessel density (LVD) in different histological types of thyroid tumors, and in their surrounding tissue, correlate with the presence of lymph node metastases (LNM) and tumor pathological features.
methodsLymph vessels of papillary thyroid carcinomas (PTC), of the classical (CVPTC,
resultsLVD within all analyzed thyroid tumor subtypes was significantly lower than in the surrounding thyroid tissues (
conclusionsAs no LVD differences were found amongst thyroid tumors with or without LNM, dissemination is more likely to depend on the tumor ability to invade the abundant lymph vessel network of the surrounding thyroid tissue than on the ability of the tumor to promote de novo lymphangiogenesis.
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