ReviewTremor and other hyperkinetic movements (New York, N.Y.)2017
Treatment of Sydenham's Chorea: A Review of the Current Evidence.
Review in Tremor and other hyperkinetic movements (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Treatments and Outcomes Among Patients with Sydenham Chorea: A Meta-Analysis.JAMA network open · 2024Pooled it
- PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation.Molecular neurobiology · 2025Review
- Investigation of Asymptomatic Rhythm and Conduction System Disorders in Pediatric Patients Diagnosed with Acute Rheumatic Fever According to Current Guidelines.Turkish archives of pediatrics · 2025Article
- A Refractory Case of Sydenham Chorea Managed With Intravenous Pulse-Dose Methylprednisolone.Case reports in pediatrics · 2025Article
- Sydenham's Chorea in Children with Acute Rheumatic Fever: An Echocardiographic Survey of Pediatric Patients in Northwestern Iran.Iranian journal of medical sciences · 2024Article
- Overview of management of infection-related movement disorders with focus on specific-infections.Clinical parkinsonism & related disorders · 2024Article
- Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience.Children (Basel, Switzerland) · 2023Article
- Rare Recurrence of Sydenham Chorea in an Adult: A Case Report.International medical case reports journal · 2023Article
- Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham's Chorea: A Multicenter Prospective Study.International journal of environmental research and public health · 2022Article
- Therapeutics for rheumatic fever and rheumatic heart disease.Australian prescriber · 2022Review
- Therapeutic aspects of Sydenham's Chorea: an update.Acta bio-medica : Atenei Parmensis · 2022Review
- Cardiac Involvement in Movement Disorders.Movement disorders clinical practice · 2021Review
- Acute Movement Disorders in Childhood.Journal of clinical medicine · 2021Review
- Treatable Hyperkinetic Movement Disorders Not to Be Missed.Frontiers in neurology · 2021Review
- Chorea in children: etiology, diagnostic approach and management.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Treatment of Disorders of Tone and Other Considerations in Pediatric Movement Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Sydenham chorea in a12- year old Saudi girl.eNeurologicalSci · 2020Article
- Preliminary data on prednisone effectiveness in children with Sydenham chorea.European journal of pediatrics · 2020Observational
- Localising movement disorders in childhood.The Lancet. Child & adolescent health · 2019Review
- Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever.Frontiers in immunology · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSydenham's chorea (SC), the neurologic manifestation of rheumatic fever, remains the most prevalent form of chorea in children. Suggested treatments of chorea in SC include prophylactic penicillin, symptomatic (antipsychotic and anticonvulsant) medications, and immunomodulatory therapy (steroids, intravenous immunoglobulin (IVIG), and plasma exchange). In this manuscript, we undertook a systematic review of the published literature to examine the data supporting these therapeutic recommendations.
methodsA search of PubMed, Embase, Psychinfo, and clinicaltrials.gov was conducted for publications pertaining to the treatment of SC/rheumatic chorea from 1956 to 2016.
resultsPenicillin prophylaxis appears to reduce the likelihood of further cardiac complications and the recurrence rate of chorea. Data on symptomatic therapy for chorea are limited to individual case reports or series and rare comparison studies. The efficacy of steroid use is supported by a single placebo-controlled study and several case series. Information on other immunomodulatory therapies such as IVIG and plasmapheresis are limited to a small number of reports and a single comparison study. DISCUSSION: Treatment decisions in SC are currently based on the treating physician's clinical experience, the desire to avoid side effects, and the existence of only limited scientific evidence. Based on a review of the available literature, chorea often improves with symptomatic therapy and immunotherapy tends to be reserved for those who fail to respond. Steroids are beneficial; however, data using IVIG and plasmapheresis are very limited. Larger, well-controlled studies, using standardized assessment scales, are required if therapeutic decisions for SC are to be based on meaningful information.
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