ArticleBMJ global health2017
Modelling the cost-effectiveness of introducing the RTS,S malaria vaccine relative to scaling up other malaria interventions in sub-Saharan Africa.
Article in BMJ global health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Models for malaria control optimization-a systematic review.Malaria journal · 2024Pooled it
- Mosquito feeding behavior and how it influences residual malaria transmission across Africa.Proceedings of the National Academy of Sciences of the United States of America · 2019Pooled it
- Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa.Nature communications · 2018Pooled it
- Agent-based models of malaria transmission: a systematic review.Malaria journal · 2018Pooled it
- An age-structured mathematical model to assess the combined effects of vaccine and non-vaccine interventions on malaria transmission and burden.Infectious Disease Modelling · 2026Article
- Estimating the impact of the RTS,S/AS01 malaria vaccine in Benin: A mathematical modelling study.PLOS global public health · 2026Article
- Provincial stratification and equity-weighted cost-effectiveness of malaria vaccines in Zambia under climate variability.BMJ public health · 2026Article
- Heterogeneous impacts for malaria control from larviciding across villages and considerations for monitoring and evaluation.PLoS pathogens · 2025Article
- Therapeutic development to accelerate malaria control through intentional intervention layering.Malaria journal · 2025Review
- The epidemiological benefit of pyrethroid-pyrrole insecticide treated nets against malaria: an individual-based malaria transmission dynamics modelling study.The Lancet. Global health · 2024Article
- LLIN Evaluation in Uganda Project (LLINEUP): modelling the impact of COVID-19-related disruptions on delivery of long-lasting insecticidal nets on malaria indicators in Uganda.Malaria journal · 2024Article
- Optimal control analysis of hepatocytic-erythrocytic dynamics ofInfectious Disease Modelling · 2022Article
- Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria.Nature communications · 2021Article
- Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S.Malaria journal · 2021Review
- Adoption of RTS, S malaria vaccine for children younger than 5 years in Rwanda: A budget impact analysis.Exploratory research in clinical and social pharmacy · 2021Article
- Operational research: A multidisciplinary approach for the management of infectious disease in a global context.European journal of operational research · 2021Article
- Maps and metrics of insecticide-treated net access, use, and nets-per-capita in Africa from 2000-2020.Nature communications · 2021Article
- Supply chain design to tackle coronavirus pandemic crisis by tourism management.Applied soft computing · 2021Article
- Force of infection: a determinant of vaccine efficacy?NPJ vaccines · 2021Review
- Considerations for Size, Surface Charge, Polymer Degradation, Co-Delivery, and Manufacturability in the Development of Polymeric Particle Vaccines for Infectious Diseases.Advanced nanobiomed research · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo evaluate the relative cost-effectiveness of introducing the RTS,S malaria vaccine in sub-Saharan Africa compared with further scale-up of existing interventions.
designA mathematical modelling and cost-effectiveness study.
settingSub-Saharan Africa.
participantsPeople of all ages.
interventionsThe analysis considers the introduction and scale-up of the RTS,S malaria vaccine and the scale-up of long-lasting insecticide-treated bed nets (LLINs), indoor residual spraying (IRS) and seasonal malaria chemoprevention (SMC).
main outcome measureThe number of
resultsAssuming access to treatment remains constant, increasing coverage of LLINs was consistently the most cost-effective intervention across a range of transmission settings and was found to occur early in the cost-effectiveness scale-up pathway. IRS, RTS,S and SMC entered the cost-effective pathway once LLIN coverage had been maximised. If non-linear production functions are included to capture the cost of reaching very high coverage, the resulting pathways become more complex and result in selection of multiple interventions.
conclusionsRTS,S was consistently implemented later in the cost-effectiveness pathway than the LLINs, IRS and SMC but was still of value as a fourth intervention in many settings to reduce burden to the levels set out in the international goals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.