ArticleUnited European gastroenterology journal2017
Prevalence and clinical features of opioid-induced constipation in the general population: A French study of 15,000 individuals.
Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pharmacological Treatment of Opioid-Induced Constipation Is Effective but Choice of Endpoints Affects the Therapeutic Gain.Digestive diseases and sciences · 2019Pooled it
- VER-01 Shows Enhanced Gastrointestinal Tolerability, Superior Pain Relief, and Improved Sleep Quality Compared to Opioids in Treating Chronic Low Back Pain: A Randomized Phase 3 Clinical Trial.Pain and therapy · 2025Article
- Treatment of Opioid-Induced Constipation: Inducing Laxation and Understanding the Risk of Gastrointestinal Perforation.Journal of clinical gastroenterology · 2025Review
- Timing of Naldemedine Initiation and Occurrence of Diarrhea in Patients Receiving Strong Opioid Analgesics: A Retrospective Study.Pharmacy (Basel, Switzerland) · 2025Article
- Efficacy of prophylactic laxatives against opioid-induced constipation: retrospective propensity score matching analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Commentary: Healthy Eating Index-2020 and bowel habits: a cross-sectional analysis of NHANES.Frontiers in nutrition · 2025Article
- Article
- Adherence to coprescribing of laxatives with opioids and associated characteristics in general practices in the Netherlands.BMC primary care · 2022Observational
- Constipation Severity and Quality of Life among Patients with Cancer Who Received Prophylactic Laxatives: Quasi-Experimental Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Opioid-Associated Anorectal Dysfunction in Chronic Constipation.Digestive diseases and sciences · 2022Article
- Prevalence of constipation and use of laxatives, and association with risk factors among older patients during hospitalization: a cross sectional study.BMC gastroenterology · 2022Article
- Opioid-Induced Constipation in Patients with Cancer Pain in Japan (OIC-J Study): A Post Hoc Analysis.Journal of clinical medicine · 2021Article
- Management of Opioid-Induced Constipation and Bowel Dysfunction: Expert Opinion of an Italian Multidisciplinary Panel.Advances in therapy · 2021Review
- Common Clinical Practice for Opioid-Induced Constipation: A Physician Survey.Journal of pain research · 2021Article
- What to Do and What Not to Do in the Management of Opioid-Induced Constipation: A Choosing Wisely Report.Pain and therapy · 2020Article
- Incidence of opioid-induced constipation in Japanese patients with cancer pain: A prospective observational cohort study.Cancer medicine · 2019Observational
- Opioid-induced constipation: a narrative review of therapeutic options in clinical management.The Korean journal of pain · 2019Article
- Pathophysiology and management of opioid-induced constipation: European expert consensus statement.United European gastroenterology journal · 2019Review
- American Gastroenterological Association Institute Technical Review on the Medical Management of Opioid-Induced Constipation.Gastroenterology · 2019Review
- Implications of Chronic Opioid Therapy on Perioperative Complications and Long-Term Surgical Recovery.Translational perioperative and pain medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConstipation is common during opioid therapy and can compromise analgesia.
aimThe aim of this article is to determine the prevalence and clinical characteristics of opioid-induced constipation (OIC) in France.
methodsA questionnaire study was conducted in a representative sample of the French general population. Participants completed a 31-item questionnaire covering opioid use during the previous six months, and the occurrence of constipation (defined as <3 bowel movements per week, straining during defaecation, or both) during opioid treatment.
resultsData were obtained from 15,213 participants, of whom 4753 (31.2%) reported opioid use. Most analgesics (96.5%) were classified as World Health Organization step II analgesics, and the remainder were step III. The most common indications for opioids were bone or joint pain, and soft tissue pain. Overall, 414/4753 (8.7%) opioid users reported OIC while the prevalence of OIC reached 21% in case of regular or prolonged (>1 month) opioid use. Other characteristics associated with OIC included female gender, age ≥50 years and use of step III opioids. Only 177/414 (42.8%) participants with OIC had used medications (most commonly osmotic laxatives) to treat constipation, and satisfaction with constipation medication was moderate (mean (SD) score 7.2 (1.3) on a scale of 0-10).
conclusionsApproximately one-third of a representative French population had used opioids within the previous six months, and 9% of users had experienced OIC, which is more frequent in case of regular use. OIC appears to be under-treated, and participants' satisfaction with their constipation medications was only moderate, suggesting that significant unmet need remains in OIC management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.