Evidence map›Paper›PMID 28588885›Full record

ArticleUnited European gastroenterology journal2017

Elevated trimethylamine-

Martin Kummen, Mette Vesterhus, Marius Trøseid, Bjørn Moum, Asbjørn Svardal, Kirsten Muri Boberg, Pål Aukrust, Tom Hemming Karlsen, Rolf Kristian Berge, Johannes Roksund Hov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Primary sclerosing cholangitis.Nature reviews. Disease primers · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. The microbiota and the gut-liver axis in primary sclerosing cholangitis.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Martin KummenNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Mette VesterhusNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Marius TrøseidK.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo, Norway.
Bjørn MoumInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Asbjørn SvardalDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Kirsten Muri BobergNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Pål AukrustK.G. Jebsen Inflammation Research Centre, University of Oslo, Oslo, Norway.
Tom Hemming KarlsenNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Rolf Kristian BergeDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Johannes Roksund HovNorwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NOHaukeland University Hospital · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrimethylamine-

objectiveThe objective of this article is to investigate the relationship between TMAO and primary sclerosing cholangitis (PSC) and its clinical characteristics.

methodsSerum TMAO was measured in 305 PSC patients, 90 ulcerative colitis patients and 99 healthy controls.

resultsIn PSC patients with normal liver function (

conclusionIn PSC patients with normal liver function, elevated TMAO was associated with shorter transplantation-free survival, potentially reflecting clinically relevant metabolic changes resulting from dietary interactions with the gut microbiota.

Indexed as

gastrointestinal microbiomePrimary sclerosing cholangitistrimethylamine-N-oxide

Identifiers

PMID28588885
PMCPMC5446140
OpenAlexW2503203035

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.