ArticleWorld journal of hepatology2017
Protein tolerance to standard and high protein meals in patients with liver cirrhosis.
Article in World journal of hepatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Review
- Nutritional Support for Alcoholic Liver Disease.Nutrients · 2023Review
- The Link between Gut Microbiota and Hepatic Encephalopathy.International journal of molecular sciences · 2022Review
- Relationship between symptoms and both stage of change in adopting a healthy life style and quality of life in patients with liver cirrhosis: a cross-sectional study.Health and quality of life outcomes · 2021Article
- Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis.World journal of hepatology · 2019Review
- EASL Clinical Practice Guidelines on nutrition in chronic liver disease.Journal of hepatology · 2019Review
- Dietary protein sources and disease severity, malnutrition and anthropometric measurements in cirrhotic patients.Gastroenterology and hepatology from bed to bench · 2019Article
- Muscle wasting and branched-chain amino acid, alpha-ketoglutarate, and ATP depletion in a rat model of liver cirrhosis.International journal of experimental pathology · 2018Article
- Nutrition in Chronic Liver Disease: Consensus Statement of the Indian National Association for Study of the Liver.Journal of clinical and experimental hepatologyReview
- Hepatic Encephalopathy and Sarcopenia: Two Faces of the Same Metabolic Alteration.Journal of clinical and experimental hepatologyReview
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Authors and funding
5 authors.
Funding
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Abstract
aimTo investigate the plasma amino acid response and tolerance to normal or high protein meals in patients with cirrhosis.
methodsThe plasma amino acid response to a 20 g mixed protein meal was compared in 8 biopsy-proven compensated cirrhotic patients and 6 healthy subjects. In addition the response to a high protein meal (1 g/kg body weight) was studied in 6 decompensated biopsy-proven cirrhotics in order to evaluate their protein tolerance and the likelihood of developing hepatic encephalopathy (HE) following a porto-caval shunt procedure. To test for covert HE, the "number connection test" (NCT) was done on all patients, and an electroencephalogram was recorded in patients considered to be at Child-Pugh C stage.
resultsThe changes in plasma amino acids after a 20 g protein meal were similar in healthy subjects and in cirrhotics except for a significantly greater increase (
conclusionPatients with stable liver disease tolerate natural mixed meals with a standard protein content. The response to a high protein meal in decompensated cirrhotics suggests accumulation of some amino acids but it did not precipitate HE. These results support current nutritional guidelines that recommend a protein intake of 1.2-1.5 g/kg body weight/day for patients with cirrhosis.
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