ArticleOxidative medicine and cellular longevity2017
The Stimulated Glycolytic Pathway Is Able to Maintain ATP Levels and Kinetic Patterns of Bovine Epididymal Sperm Subjected to Mitochondrial Uncoupling.
Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- L-Selenomethionine Alleviates Cryo-Induced Ferroptosis Through the NRF2-SLC7A11-GPX4 Pathway, Improving Post-Thaw In Vitro Quality of Dairy Goat Spermatozoa.Antioxidants (Basel, Switzerland) · 2026Article
- Lactate inhibits glucose-induced zigzag motility and enhances linear motility in bull spermatozoa by suppressing glycolysis.Andrology · 2026Article
- Triclocarban impacts human sperm motility by inhibiting glycolysis and oxidative phosphorylation.Asian journal of andrology · 2025Article
- A Step Toward ESIPT-Based Mitochondrial Probe That Responds to ATP Level.Advanced sensor research · 2025Article
- Sperm-Borne Mitochondrial Activity Influenced by Season and Age of Holstein Bulls.International journal of molecular sciences · 2024Article
- Exogenous Oxidative Stress in Human Spermatozoa Induces Opening of the Mitochondrial Permeability Transition Pore: Effect on Mitochondrial Function, Sperm Motility and Induction of Cell Death.Antioxidants (Basel, Switzerland) · 2024Article
- mitoBKeLife · 2024Article
- Expression of miR-138 in cryopreserved bovine sperm is related to their fertility potential.Journal of animal science and biotechnology · 2023Article
- Post-Thaw Parameters of Buck Semen Quality after Soy Lecithin Extender Supplementation with Fumaric Acid.Veterinary sciences · 2023Article
- Sperm physiology and in vitro fertilising ability rely on basal metabolic activity: insights from the pig model.Communications biology · 2023Article
- Natural Astaxanthin Improves Testosterone Synthesis and Sperm Mitochondrial Function in Aging Roosters.Antioxidants (Basel, Switzerland) · 2022Article
- Mitoquinone does not improve sperm cryo-resistance in bulls.Reproduction in domestic animals = Zuchthygiene · 2022Article
- Mitochondria Content and Activity Are Crucial Parameters for Bull Sperm Quality Evaluation.Antioxidants (Basel, Switzerland) · 2021Article
- Pathophysiology of Mitochondrial Dysfunction in Human Spermatozoa: Focus on Energetic Metabolism, Oxidative Stress and Apoptosis.Antioxidants (Basel, Switzerland) · 2021Review
- Mitochondrial Dysfunction and Oxidative Stress Caused by Cryopreservation in Reproductive Cells.Antioxidants (Basel, Switzerland) · 2021Review
- Advancing Semen Evaluation Using Lipidomics.Frontiers in veterinary science · 2021Review
- Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility.Journal of clinical medicine · 2020Review
- The motility-based swim-up technique separates bull sperm based on differences in metabolic rates and tail length.PloS one · 2019Article
- Antioxidant Effect of a Polyphenol-Rich Murtilla (Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have reported the importance of mitochondria in sperm functionality. However, for some species, the glycolytic pathway appears to be as important as oxidative phosphorylation in ATP synthesis and sperm kinetics. These mechanisms have not been fully elucidated for bovine spermatozoa. Therefore, the aim of this study was to evaluate the role of mitochondria and the glycolytic pathway in ATP synthesis, sperm movement patterns, and oxidative homeostasis of epididymal spermatozoa in bovine specimens. We observed that mitochondrial uncoupling with protonophores significantly reduced ATP levels. However, these levels were reestablished after stimulation of the glycolytic pathway. We verified the same pattern of results for sperm kinetic variables and the production of reactive oxygen species (ROS). Thus, we suggest that, after its appropriate stimulation, the glycolytic pathway is capable of maintaining ATP levels, sperm kinetic patterns, and oxidative balance of bovine epididymal spermatozoa submitted to mitochondrial uncoupling.
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