ArticleClinical epigenetics2017
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- The Association Between Personal Air Pollution Exposures and Fractional Exhaled Nitric Oxide (FeNO): A Systematic Review.Current environmental health reports · 2024Pooled it
- Blood DNA methylation as a potential biomarker of dementia: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- The epigenetic-immune-microbiome axis in early life: reprogramming the origins and endotypes of pediatric asthma.Frontiers in immunology · 2026Review
- Examining the Interaction between Allergic Asthma and Air Pollution: a Potential Role for Trained Immunity.Current allergy and asthma reports · 2025Review
- The Role of Environmental Exposures in Pediatric Asthma Pathogenesis: A Contemporary Narrative Review.Children (Basel, Switzerland) · 2025Review
- Impact of climate change on paediatric respiratory health: pollutants and aeroallergens.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children's Environmental Health.International journal of epidemiology · 2024Article
- Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months.Environmental research · 2023Article
- Early-life exposure to residential black carbon and childhood cardiometabolic health.Environmental research · 2023Article
- Characteristics of peak exposure to black carbon pollution in school, commute and home environments among school children in an urban community.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis.Current allergy and asthma reports · 2022Review
- Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- Assessment and mitigation of toddlers' personal exposure to black carbon before and during the COVID-19 pandemic: A case study in Singapore.Environmental research · 2021Article
- Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City.Environmental health perspectives · 2021Article
- Prenatal polycyclic aromatic hydrocarbons, altered ERα pathway-related methylation and expression, and mammary epithelial cell proliferation in offspring and grandoffspring adult mice.Environmental research · 2021Article
- A review of epigenetic changes in asthma: methylation and acetylation.Clinical epigenetics · 2021Review
- Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.Environmental health : a global access science source · 2021Article
- A Comparison of Activity Participation between Children with and without Asthma.The open journal of occupational therapy · 2021Article
- Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma.International journal of molecular sciences · 2020Review
- Epigenetic Changes in Asthma: Role of DNA CpG Methylation.Tuberculosis and respiratory diseases · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAsthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not been fully elucidated. Our objective was to determine the timeline of black carbon (BC) exposure, measured by personal sampling, on DNA methylation of allergic asthma genes 5 days later to capture usual weather variations and differences related to changes in behavior and activities. We also sought to determine how methylation may vary by seroatopy and cockroach sensitization and by elevated fractional exhaled nitric oxide (FeNO).
methodsPersonal BC levels were measured during two 24-h periods over a 6-day sampling period in 163 New York City children (age 9-14 years), repeated 6 months later. During home visits, buccal cells were collected as noninvasive surrogates for lower airway epithelial cells and FeNO measured as an indicator of airway inflammation. CpG promoter loci of allergic asthma genes (e.g., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitric oxide synthase (NOS2A)), arginase 2 (ARG2)) were pyrosequenced at the start and end of each sampling period.
resultsHigher levels of BC were associated with lower methylation of IL4 promoter CpG
conclusionsOur results suggest that exposure to BC may exert asthma proinflammatory gene demethylation 5 days later that in turn may link to airway inflammation. Our results further suggest that seroatopic children, especially those sensitized to cockroach allergens, may be more susceptible to the effect of acute BC exposure on epigenetic changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.