Evidence map›Paper›PMID 28588666›Full record

ArticleExperimental and therapeutic medicine2017

Molecular analysis of the novel

Lukana Ngiwsara, Kitiwan Rojnueangnit, Duangrurdee Wattanasirichaigoon, Thipwimol Tim-Aroon, Phannee Sawangareetrakul, Voraratt Champattanachai, James R Ketudat-Cairns, Jisnuson Svasti

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Lukana NgiwsaraLaboratory of Biochemistry, Chulaborn Research Institute, Bangkok 10210, Thailand.
Kitiwan RojnueangnitPediatrics Department, Faculty of Medicine, Thammasat University, Bangkok 10200, Thailand.
Duangrurdee WattanasirichaigoonDepartment of Pediatrics, Division of Medical Genetics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Thipwimol Tim-AroonDepartment of Pediatrics, Division of Medical Genetics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Phannee SawangareetrakulLaboratory of Biochemistry, Chulaborn Research Institute, Bangkok 10210, Thailand.
Voraratt ChampattanachaiLaboratory of Biochemistry, Chulaborn Research Institute, Bangkok 10210, Thailand.
James R Ketudat-CairnsLaboratory of Biochemistry, Chulaborn Research Institute, Bangkok 10210, Thailand.
Jisnuson SvastiLaboratory of Biochemistry, Chulaborn Research Institute, Bangkok 10210, Thailand.
Chulabhorn Research Institute · THMahidol University · THRamathibodi Hospital · THSuranaree University of Technology · THThammasat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hunter syndrome (or mucopolysaccharidosis type II, MPS II) is an X-linked recessive disorder induced by a deficiency of the iduronate 2-sulfatase (IDS) enzyme, resulting in the accumulation of glycosaminoglycan substrates, heparan sulfate and dermatan sulfate, in the lysosomes. The progressive accumulation of undegraded metabolites induces cell and tissue dysfunction, leading to multi-systemic pathology. The heterogeneity of clinical phenotypes, ranging from mild to severe forms, results from different mutations in the

Indexed as

iduronate 2-sulfatasemucopolysaccharidosis type IInonsense mediated mRNA decay

Identifiers

PMID28588666
PMCPMC5450777
OpenAlexW2604881740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.