ArticleFrontiers in genetics2017
An Enhancer's Length and Composition Are Shaped by Its Regulatory Task.
Article in Frontiers in genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Genomic language model for predicting enhancers and their allele-specific activity in the human genome.Bioinformatics (Oxford, England) · 2026Article
- An Outflow Tract Myocardium-Specific Enhancer at the Sema3c Locus During Heart Development.Genes to cells : devoted to molecular & cellular mechanisms · 2026Article
- Programming human cell type-specific gene expression via an atlas of AI-designed enhancers.bioRxiv : the preprint server for biology · 2025Article
- Prediction of local convergent shifts in evolutionary rates with phyloConverge.Bioinformatics (Oxford, England) · 2025Article
- Impact of putatively beneficial genomic loci on gene expression in little brown bats (Evolutionary applications · 2024Article
- Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation.Genome biology · 2024Article
- Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.JCI insight · 2024Article
- Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation.bioRxiv : the preprint server for biology · 2024Article
- Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation.Developmental cell · 2023Article
- Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development.Developmental cell · 2023Article
- A body map of super-enhancers and their function in pig.Frontiers in veterinary science · 2023Article
- Bioinformatic Evaluation of Features on Cis-regulatory Elements at 6q25.1.Bioinformatics and biology insights · 2023Review
- Function and Constraint in Enhancer Sequences with Multiple Evolutionary Origins.Genome biology and evolution · 2022Article
- A map of cis-regulatory modules and constituent transcription factor binding sites in 80% of the mouse genome.BMC genomics · 2022Article
- Article
- Epigenetics of neural differentiation: Spotlight on enhancers.Frontiers in cell and developmental biology · 2022Review
- Article
- An explainable artificial intelligence approach for decoding the enhancer histone modifications code and identification of novel enhancers in Drosophila.Genome biology · 2021Article
- Global properties of regulatory sequences are predicted by transcription factor recognition mechanisms.Genome biology · 2021Article
- DECODE: a Deep-learning framework for Condensing enhancers and refining boundaries with large-scale functional assays.Bioinformatics (Oxford, England) · 2021Article
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2 authors.
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Abstract
Enhancers drive the gene expression patterns required for virtually every process in metazoans. We propose that enhancer length and transcription factor (TF) binding site composition-the number and identity of TF binding sites-reflect the complexity of the enhancer's regulatory task. In development, we define regulatory task complexity as the number of fates specified in a set of cells at once. We hypothesize that enhancers with more complex regulatory tasks will be longer, with more, but less specific, TF binding sites. Larger numbers of binding sites can be arranged in more ways, allowing enhancers to drive many distinct expression patterns, and therefore cell fates, using a finite number of TF inputs. We compare ~100 enhancers patterning the more complex anterior-posterior (AP) axis and the simpler dorsal-ventral (DV) axis in
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.