ArticleFrontiers in neurology2017
Improving Dual-Task Walking Paradigms to Detect Prodromal Parkinson's and Alzheimer's Diseases.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Effect of virtual reality training on dual-task performance in older adults: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- The Acute and Chronic Effects of Dual-Task on the Motor and Cognitive Performances in Athletes: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Walking as a Window to the Brain: Redefining Gait in Neurology.Medical sciences (Basel, Switzerland) · 2026Review
- Features of Prodromal Parkinson Disease and Dopaminergic Neurotransmission in Community-Dwelling Older Adults.Neurology · 2025Observational
- Dual-Task Performance and Brain Morphologic Characteristics in Parkinson's Disease.Neuro-degenerative diseases · 2024Article
- Dual-task costs in speed tasks: a comparison between elite ice hockey, open-skill and closed-skill sports athletes.Frontiers in psychology · 2024Article
- Freezing of Gait in Parkinson's Disease: Implications for Dual-Task Walking.Journal of Parkinson's disease · 2023Article
- A Review of the Measurement of the Neurology of Gait in Cognitive Dysfunction or Dementia, Focusing on the Application of fNIRS during Dual-Task Gait Assessment.Brain sciences · 2022Review
- A Novel Way of Measuring Dual-Task Interference: The Reliability and Construct Validity of the Dual-Task Effect Battery in Neurodegenerative Disease.Neurorehabilitation and neural repair · 2022Article
- The Relationships of Fibrinogen and C-Reactive Protein With Gait Performance: A 20-Year Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- High Sensory Responsiveness in Older Adults is Associated with Walking Outside but Not Inside: Proof of Concept Study.Clinical interventions in aging · 2021Article
- Assessing a Sensory-Motor-Cognition Triad in Amnestic Mild Cognitive Impairment With Dichotic Listening While Walking: A Dual-Task Paradigm.Frontiers in aging neuroscience · 2021Article
- Article
- Dual tasking impairments are associated with striatal pathology in Huntington's disease.Annals of clinical and translational neurology · 2020Article
- Goalkeeper Game: A New Assessment Tool for Prediction of Gait Performance Under Complex Condition in People With Parkinson's Disease.Frontiers in aging neuroscience · 2020Article
- Dual vs. Single Tasking During Circular Walking: What Better Reflects Progression in Parkinson's Disease?Frontiers in neurology · 2019Article
- Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer's Disease Cerebrospinal Fluid Biomarkers.Journal of Alzheimer's disease : JAD · 2019Article
- Which cognitive dual-task walking causes most interference on the Timed Up and Go test in Parkinson's disease: a controlled study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Cognitive-Motor Interference during Walking in Older Adults with Probable Mild Cognitive Impairment.Frontiers in aging neuroscience · 2017Article
- Lactoferrin-Loaded PEG/PLA Block Copolymer Targeted With Anti-Transferrin Receptor Antibodies for Alzheimer Disease.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gait control is a complex movement, relying on spinal, subcortical, and cortical structures. The presence of deficits in one or more of these structures will result in changes in gait automaticity and control, as is the case in several neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). By reviewing recent findings in this field of research, current studies have shown that gait performance assessment under dual-task conditions could contribute to predict both of these diseases. Such suggestions are relevant mainly for people at putatively high risk of developing AD (i.e., older adults with mild cognitive impairment subtypes) or PD (i.e., older adults with either Mild Parkinsonian signs or LRRK2 G2019S mutation). Despite the major importance of these results, the type of cognitive task that should be used as a concurrent secondary task has to be selected among the plurality of tasks proposed in the literature. Furthermore, the key aspects of gait control that represent sensitive and specific "gait signatures" for prodromal AD or PD need to be determined. In the present perspective article, we suggest the use of a Stroop interference task requiring inhibitory attentional control and a set-shifting task requiring reactive flexibility as being particularly relevant secondary tasks for challenging gait in prodromal AD and PD, respectively. Investigating how inhibition and cognitive flexibility interfere with gait control is a promising avenue for future research aimed at enhancing early detection of AD and PD, respectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.