ReviewFrontiers in neurology2017
Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06029920 (The Effect of Overground Walking on the Increase of Brain-Derived Neurotrophic Factor Levels, IL-6, HS-CRP, Cognitive Function, and Quality of Life in the Elderly), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Overground Walking on the Increase of Brain-Derived Neurotrophic Factor Levels, IL-6, HS-CRP, Cognitive Function, and Quality of Life in the Elderly
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Physical activity and exercise in primary open-angle glaucoma: a scoping review.Frontiers in physiology · 2026Pooled it
- Health Benefits of Endurance Training: Implications of the Brain-Derived Neurotrophic Factor-A Systematic Review.Neural plasticity · 2019Pooled it
- Single Nucleotide Polymorphisms in Orexin-1 and BDNF Receptor Genes are Associated with Increased Risk of Developing Postpartum Depression among Women with Gestational Diabetes Mellitus.Public health genomics · 2026Article
- Neuroprotective cellular and molecular mechanisms of physical exercise on neurodegenerative diseases.ADMET & DMPK · 2026Review
- The Neuroprotective Potential of Vitamin DNutrients · 2025Review
- The Role of Physical Activity on Spatial and Temporal Cognitive Processing in Young Women.Brain sciences · 2025Article
- Moving beyond animal models: enriched environments and human substance use disorders.Frontiers in behavioral neuroscience · 2025Article
- The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity.International journal of obesity (2005) · 2024Review
- Effects of aerobic exercise on children's executive function and academic performance: A systematic review and meta-analysis.Heliyon · 2024Article
- Dissecting the causal relationship between moderate to vigorous physical activity levels and cognitive performance: a bidirectional two-sample Mendelian randomization study.Frontiers in psychology · 2024Article
- Exercise and Schizophrenia.Current topics in behavioral neurosciences · 2024Review
- The Association of Physical Activity with Glaucoma and Related Traits in the UK Biobank.Ophthalmology · 2023Observational
- Sex-specific relationships between obesity, physical activity, and gray and white matter volume in cognitively unimpaired older adults.GeroScience · 2023Article
- Do psychological distress and digital sports influence the willingness to take the vaccine and precautionary saving? Empirical evidence from Shanghai.Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2023Article
- Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial.Frontiers in aging neuroscience · 2023Article
- The Influence of Physical Exercise Frequency and Intensity on Individual Entrepreneurial Behavior: Evidence from China.International journal of environmental research and public health · 2022Article
- Actigraphy-estimated physical activity is associated with functional and structural brain connectivity among older adults.Neurobiology of aging · 2022Article
- Physiological Role of Orexinergic System for Health.International journal of environmental research and public health · 2022Review
- Software professionals during the COVID-19 pandemic in Turkey: Factors affecting their mental well-being and work engagement in the home-based work setting.The Journal of systems and software · 2022Article
- Boosting effect of regular sport practice in young adults: Preliminary results on cognitive and emotional abilities.Frontiers in psychology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present article, we provide a review of current knowledge regarding the role played by physical activity (PA) in preventing age-related cognitive decline and reducing risk of dementia. The cognitive benefits of PA are highlighted by epidemiological, neuroimaging and behavioral studies. Epidemiological studies identified PA as an influential lifestyle factor in predicting rates of cognitive decline. Individuals physically active from midlife show a reduced later risk of cognitive impairment. Neuroimaging studies documented attenuation of age-related brain atrophy, and also increase of gray matter and white matter of brain areas, including frontal and temporal lobes. These structural changes are often associated with improved cognitive performance. Importantly, the brain regions that benefit from PA are also those regions that are often reported to be severely affected in dementia. Animal model studies provided significant information about biomechanisms that support exercise-enhanced neuroplasticity, such as angiogenesis and upregulation of growth factors. Among the growth factors, the brain-derived neurotrophic factor seems to play a significant role. Another putative factor that might contribute to beneficial effects of exercise is the neuropeptide orexin-A. The beneficial effects of PA may represent an important resource to hinder the cognitive decline associated with aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.