Evidence map›Paper›PMID 28588475›Full record

ArticleFrontiers in aging neuroscience2017

Distinct Role of Striatal Functional Connectivity and Dopaminergic Loss in Parkinson's Symptoms.

Juergen Dukart, Fabio Sambataro, Alessandro Bertolino

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Progressive Decline in Gray and White Matter Integrity inFrontiers in aging neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juergen DukartRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Discovery and Translational Area, Roche Innovation Center BaselBasel, Switzerland.
Fabio SambataroRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Discovery and Translational Area, Roche Innovation Center BaselBasel, Switzerland.
Alessandro BertolinoRoche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Discovery and Translational Area, Roche Innovation Center BaselBasel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degeneration of dopaminergic neurons is a hallmark of Parkinson's disease. However, its link to Parkinson's disease symptoms remains unclear. Striatal resting state functional connectivity differentiates between Parkinson's disease patients and healthy controls and might be a potential mediator of the effects of striatal dopaminergic degeneration onto Parkinson's disease symptoms. Here, we evaluated the relationship between dopaminergic deficits, striatal functional connectivity (SFC) at rest and different Parkinson's disease clinical symptoms in the largest currently established cohort of

Indexed as

clinical symptomsDAT-SPECTParkinson’s diseasestriatal functional connectivityUnified Parkinson’s Disease Rating Scale

Identifiers

PMID28588475
PMCPMC5441129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.