ReviewFrontiers in cellular neuroscience2017
Refining the Role of 5-HT in Postnatal Development of Brain Circuits.
Review in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 105 citations in OpenAlex.
- Lactational Serotonergic Perturbation Imprints Stress-Related Transcriptional Profiles in the Adolescent Female Rat Prefrontal Cortex.ACS chemical neuroscience · 2026Article
- The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk.Cellular and molecular neurobiology · 2026Review
- Serotonergic modulation of excitatory synapse development and plasticity.Molecules and cells · 2026Review
- Sex-dependent serotonergic signaling across development: molecular mechanisms shaping vulnerability to neurodevelopmental and mental disorders.Frontiers in pharmacology · 2026Review
- Article
- High Resolution Postmortem MRI Discovers Developing Structural Connectivity in the Human Ascending Arousal Network.Human brain mapping · 2025Article
- Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning.PLoS biology · 2025Article
- Revisiting the Role of Serotonin in Attention-Deficit Hyperactivity Disorder: New Insights from Preclinical and Clinical Studies.Clinical drug investigation · 2025Review
- Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension.JAACAP open · 2025Article
- Unveiling GABA and Serotonin Interactions During Neurodevelopment to Re-Open Adult Critical Periods for Neuropsychiatric Disorders.International journal of molecular sciences · 2025Review
- Chronic Fluoxetine Treatment Desensitizes Serotoninergic Inhibition of GABAergic Inputs and Intrinsic Excitability of Dorsal Raphe Serotonin Neurons.Brain sciences · 2025Article
- Alterations of Adult Prefrontal Circuits Induced by Early Postnatal Fluoxetine Treatment Mediated by 5-HT7 Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The organization of serotonergic fibers in the Pacific angelshark brain: neuroanatomical and supercomputing analyses.Frontiers in neuroscience · 2025Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.iScience · 2024Article
- Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination.PLoS biology · 2024Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
- Olfactory Critical Periods: How Odor Exposure Shapes the Developing Brain in Mice and Flies.Biology · 2024Review
- Plasticity of thalamocortical axons is regulated by serotonin levels modulated by preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.Translational psychiatry · 2023Article
- Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills.Molecular psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in development has long-lasting effects on brain function, particularly on later anxiety/depression-related behaviors in adulthood. A large part of the known developmental effects of 5-HT occur during critical periods of postnatal life, when activity-dependent mechanisms remodel neural circuits. This was first demonstrated for the maturation of sensory brain maps in the barrel cortex and the visual system. More recently this has been extended to the 5-HT raphe circuits themselves and to limbic circuits. Recent studies overviewed here used new genetic models in mice and rats and combined physiological and structural approaches to provide new insights on the cellular and molecular mechanisms controlled by 5-HT during late stages of neural circuit maturation in the raphe projections, the somatosensory cortex and the visual system. Similar mechanisms appear to be also involved in the maturation of limbic circuits such as prefrontal circuits. The latter are of particular relevance to understand the impact of transient 5-HT dysfunction during postnatal life on psychiatric illnesses and emotional disorders in adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.