ArticleInternational journal of obesity (2005)2017
Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.Molecular medicine (Cambridge, Mass.) · 2021Pooled it
- Insulin resistance in obese children and adolescents: from mechanisms to screening and exercise intervention.Frontiers in pediatrics · 2026Review
- Urinary amino acid metabolomic profiling and its association with childhood obesity in prepubescent individuals.Frontiers in physiology · 2025Article
- Probing erythrocytes as sensitive and reliable sensors of metabolic disturbances in the crosstalk between childhood obesity and insulin resistance: findings from an observational study, in vivo challenge tests, and ex vivo incubation assays.Cardiovascular diabetology · 2024Observational
- Article
- The link between obesity and insulin resistance among children: Effects of key metabolites.Journal of diabetes · 2023Article
- Childhood Obesity and the Cryptic Language of the Microbiota: Metabolomics' Upgrading.Metabolites · 2023Review
- Identifying subgroups of childhood obesity by using multiplatform metabotyping.Frontiers in molecular biosciences · 2023Article
- Amino acid profile in overweight and obese prepubertal children - can simple biochemical tests help in the early prevention of associated comorbidities?Frontiers in endocrinology · 2023Article
- The Role of Molecular and Hormonal Factors in Obesity and the Effects of Physical Activity in Children.International journal of molecular sciences · 2022Review
- NMR-based metabolic profiling of children with premature adrenarche.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health.eLife · 2022Article
- Omics era in type 2 diabetes: From childhood to adulthood.World journal of diabetes · 2021Review
- Insulin Resistance in Obese Children: What Can Metabolomics and Adipokine Modelling Contribute?Nutrients · 2020Review
- Article
- Ethnicity Strongly Influences Body Fat Distribution Determining Serum Adipokine Profile and Metabolic Derangement in Childhood Obesity.Frontiers in pediatrics · 2020Article
- A preliminary transcriptome analysis suggests a transitory effect of vitamin D on mitochondrial function in obese young Finnish subjects.Endocrine connections · 2019Article
- Metabolomics approach byArthritis research & therapy · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesInsulin resistance (IR) is the cornerstone of the obesity-associated metabolic derangements observed in obese children. Targeted metabolomics was employed to explore the pathophysiological relevance of hyperinsulinemia in childhood obesity in order to identify biomarkers of IR with potential clinical application. SUBJECTS/
methodsOne hundred prepubertal obese children (50 girls/50 boys, 50% IR and 50% non-IR in each group), underwent an oral glucose tolerance test for usual carbohydrate and lipid metabolism determinations. Fasting serum leptin, total and high molecular weight-adiponectin and high-sensitivity C-reactive protein (CRP) levels were measured and the metabolites showing significant differences between IR and non-IR groups in a previous metabolomics study were quantified. Enrichment of metabolic pathways (quantitative enrichment analysis) and the correlations between lipid and carbohydrate metabolism parameters, adipokines and serum metabolites were investigated, with their discriminatory capacity being evaluated by receiver operating characteristic (ROC) analysis.
resultsTwenty-three metabolite sets were enriched in the serum metabolome of IR obese children (P<0.05, false discovery rate (FDR)<5%). The urea cycle, alanine metabolism and glucose-alanine cycle were the most significantly enriched pathways (P
conclusionsCombined sets of metabolic, adipokine and metabolomic parameters can identify pathophysiological relevant IR in a single fasting sample, suggesting a potential application of metabolomic analysis in clinical practice to better identify children at risk without using invasive protocols.
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