ArticleScientific reports2017
Retinol-binding protein-4 expression marks the short-term mortality of critically ill patients with underlying liver disease: Lipid, but not glucose, matters.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Inflammation-linked adipokine profiles associate with acute organ dysfunction after severe trauma.Journal of translational medicine · 2026Article
- Overcoming barriers to early diagnosis and treatment of p.Val142Ile amyloid transthyretin (ATTR) cardiomyopathy.Heart failure reviews · 2026Review
- Usefulness of Retinol-Binding Protein in Predicting Mortality in Patients With Chronic Liver Disease.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Association of baseline and longitudinal plasma retinol-binding protein 4 with all-cause mortality in maintenance hemodialysis patients.Frontiers in endocrinology · 2025Article
- Association between Circulating Retinol Binding Protein 4, Body Mass Index, and Biomarkers of Environmental Enteric Dysfunction among Slum-Dwelling Lean Adults in Bangladesh.The American journal of tropical medicine and hygiene · 2022Article
- A Prognostic Model for In-Hospital Mortality in Critically Ill Patients with Pneumonia.Infection and drug resistance · 2022Article
- Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter.Virulence · 2020Article
- Serum retinol-binding protein 4 as a predictor of cardiovascular events in elderly patients with chronic heart failure.ESC heart failure · 2020Article
- The Role of Adipokines as Circulating Biomarkers in Critical Illness and Sepsis.International journal of molecular sciences · 2019Review
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The implications of retinol-binding protein-4 (RBP4) expression in critically ill patients with underlying liver diseases remain unclear. A prospective cohort study involving 200 liver intensive care unit (ICU) patients was conducted, with 274 blood donors as controls. Patient outcomes were assessed using Cox and Kaplan-Meier analyses. Of the 200 ICU patients (mean age: 56.0 yrs), 79.5% were male, 72.5% were cirrhotic, 62% were septic, 29.5% were diabetic, and 29% expired in the ICU (median admission: 7.5 days). ICU patients had lower baseline RBP4 (25.6+/-18.4 vs. 43.8+/-35.0 mg/L, p < 0.001) and total cholesterol (TC) levels than controls. The surviving ICU patients had lower baseline international normalized ratios (INRs) of prothrombin time, model for end-stage liver disease (MELD) scores and sepsis rates, but higher estimated glomerular filtration rates (eGFRs) and RBP4 levels than non-surviving patients. eGFRs, INRs and TC levels were independently associated with RBP4 levels. Only surviving patients exhibited significantly increased RBP4 levels after ICU discharge. Baseline RBP4 levels and MELD scores predicted 21-day (≤10 mg/L) and 1-year (≥25) mortality, respectively. In critically ill patients with underlying liver disease, with a link to eGFRs, INRs and TC levels, the baseline RBP4 may serve as a marker for short-term mortality.
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