Evidence map›Paper›PMID 28588210›Full record

ArticleScientific reports2017

Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs.

Wei Qi, Longlong Tian, Wenzhen An, Qiang Wu, Jianli Liu, Can Jiang, Jun Yang, Bing Tang, Yafeng Zhang, Kangjun Xie and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Toxicity of multi-wall carbon nanotubes inhalation on the brain of rats.Environmental science and pollution research international · 2020
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Wei QiSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan City, 430074, Hubei Province, P.R. China. qiwei@hust.edu.cn.
Longlong TianLanzhou University, Lanzhou City, 730000, Gansu Province, P.R. China.
Wenzhen AnLanzhou University, Lanzhou City, 730000, Gansu Province, P.R. China.
Qiang WuLanzhou University, Lanzhou City, 730000, Gansu Province, P.R. China.
Jianli LiuLanzhou University Second Hospital, Lanzhou City, 730000, Gansu Province, P.R. China.
Can JiangNon-power Nuclear Technology Research & Development Center, Hubei University of Science and Technology, Xianning City, 437000, Hubei Province, P.R. China.
Jun YangInstitue of Applied and Electromagnetic Engineering, Huazhong University of Science and Technology, Wuhan City, 430074, Hubei Province, P.R. China.
Bing TangInstitue of Applied and Electromagnetic Engineering, Huazhong University of Science and Technology, Wuhan City, 430074, Hubei Province, P.R. China.
Yafeng ZhangInstitue of Applied and Electromagnetic Engineering, Huazhong University of Science and Technology, Wuhan City, 430074, Hubei Province, P.R. China.
Kangjun XieSchool of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan City, 430074, Hubei Province, P.R. China.
Xinling WangCollege of Pharmacy, Xinjiang Medical University, Urumqi, 830011, Xinjiang Province, P.R. China.
Zhan LiLanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, Gansu Province, P.R. China. lizhaner@126.com.
Wangsuo WuLanzhou University, Lanzhou City, 730000, Gansu Province, P.R. China. wuws@lzu.edu.cn.
Huazhong University of Science and Technology · CNLanzhou University · CNChinese Academy of Sciences · CNHuazhong Agricultural University · CNHubei University of Science and Technology · CNLanzhou University Second Hospital · CNXinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the development and application of nanotechnology, large amounts of nanoparticles will be potentially released to the environment and possibly cause many severe health problems. Although the toxicity of nanoparticles has been investigated, prevention and treatment of damages caused by nanoparticles have been rarely studied. Therefore, isotope tracing and improved CT imaging techniques were used to investigate the biodistribution influence between oMWCNTs(oxidized multi-walled carbon nanotubes) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/or simvastatin (TD) in vivo. What's more, biochemical indices in plasma and tissue histology were measured to further study therapeutic effects on the damages of oMWCNTs in mice. Isotope tracing and improved CT imaging results showed that low dosages of DOPC and TD didn't affect the distribution of oMWCNTs in mice; conversely, the distribution and metabolism of DOPC and TD were influenced by oMWCNTs. Moreover, DOPC and/or TD improved the biocompatibility of oMWCNTs in erythrocyte suspension in vitro. Biochemical index and histopathological results indicated that DOPC and TD didn't prevent injuries caused by oMWCNTs effectively. But TD showed a good therapeutic effect for damages. This study is the first to investigate prevention and treatment effects of drugs on damages caused by oMWCNTs and provides new insights and breakthroughs for management of nanoparticles on health hazards.

Indexed as

NanotechnologyAnimalsHumansMiceNanotubes, CarbonOxidation-ReductionPhosphatidylcholinesSimvastatinTissue Distribution1,2-oleoylphosphatidylcholineNanotubes, CarbonPhosphatidylcholinesSimvastatin

Identifiers

PMID28588210
PMCPMC5460272
OpenAlexW2619755052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.