ArticleScience signaling2017
Radiation inhibits salivary gland function by promoting STIM1 cleavage by caspase-3 and loss of SOCE through a TRPM2-dependent pathway.
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Article in Science signaling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Radiation-Induced Salivary Gland Fibrosis: Mechanisms, Emerging Therapies, and Gelatin-Based Bioengineered Models.Gels (Basel, Switzerland) · 2026Review
- Review
- Targeted regeneration of post-radiation epithelium without promoting cancer recurrence.Research square · 2026Article
- Melatonin may be an alternative to amifostine in salivary gland protection in irradiated rats.BMC oral health · 2025Article
- Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling.bioRxiv : the preprint server for biology · 2025Article
- Hydrogen peroxide disrupts the regulatory pathway of saliva secretion in two salivary acinar rat cell lines.Frontiers in molecular biosciences · 2024Article
- Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration.International journal of oral science · 2023Review
- A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses.Journal of dental research · 2023Article
- Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury.International journal of molecular sciences · 2023Article
- Metabolomics analysis of pathways underlying radiation-induced salivary gland dysfunction stages.PloS one · 2023Article
- Short-term and bystander effects of radiation on murine submandibular glands.Disease models & mechanisms · 2022Article
- Salivary gland function, development, and regeneration.Physiological reviews · 2022Review
- Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype.PNAS nexus · 2022Article
- Review
- TRP Channels as Molecular Targets to Relieve Endocrine-Related Diseases.Frontiers in molecular biosciences · 2022Review
- Diagnosis, Prevention, and Treatment of Radiotherapy-Induced Xerostomia: A Review.Journal of oncology · 2022Review
- Mechanism, Prevention, and Treatment of Radiation-Induced Salivary Gland Injury Related to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation.Experimental and therapeutic medicine · 2021Article
- Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin EFrontiers in bioengineering and biotechnology · 2021Article
- X-Ray Causes mRNA Transcripts Change to Enhance Orai2-Mediated CaFrontiers in molecular biosciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Xibao LiuMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.ORCID http://orcid.org/0000-0002-9640-2850
Baijuan GongDepartment of Orthodontics, Jilin University School of Stomatology, Changchun 130021, People's Republic of China.
Lorena Brito de SouzaMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Hwei Ling OngMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Krishna P SubediMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Kwong Tai ChengMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
William SwaimMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.ORCID http://orcid.org/0000-0002-2880-6378
Changyu ZhengMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Yasuo MoriLaboratory of Molecular Biology, Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Indu S AmbudkarMolecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. indu.ambudkar@nih.gov.ORCID http://orcid.org/0000-0002-9559-8679
National Institutes of Health · USJilin University · CNKyoto University · JP
Funding
Molecular Mechanisms Regulating Calcium Flux In Salivary GlandsZIADE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 2009 to 2025
$42.5MMolecular Regulaton Calcium Flux In Salivary GlandsZ01DE000438 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI AMBUDKAR, INDU S. · 1987 to 2008
$3.6MIntramural NIH HHS Z01 DE000438Intramural NIH HHS ZIA DE000438
Abstract
Store-operated Ca
Indexed as
Acinar CellsAnimalsCalciumCalcium ChannelsCaspase 3Cells, CulturedHumansMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, KnockoutMitochondriaORAI1 ProteinRadiotherapySalivary GlandsStromal Interaction Molecule 1CalciumCalcium ChannelsCaspase 3ORAI1 ProteinStromal Interaction Molecule 1TRPM2 protein, mouseTRPM Cation Channels
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.