Evidence map›Paper›PMID 28588059›Full record

ArticleMolecular cancer research : MCR2017

Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody.

Tadanobu Nagaya, Yuko Nakamura, Shuhei Okuyama, Fusa Ogata, Yasuhiro Maruoka, Peter L Choyke, Hisataka Kobayashi

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
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  9. Preclinical Evaluation of an Integrin αBioconjugate chemistry · 2025
    Article
  10. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
  11. Review
  12. Article
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  15. Review
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  18. Near-infrared photoimmunotherapy (NIR-PIT) of bone metastases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tadanobu NagayaMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Yuko NakamuraMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Shuhei OkuyamaMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Fusa OgataMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Yasuhiro MaruokaMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Peter L ChoykeMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Hisataka KobayashiMolecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. kobayash@mail.nih.gov.
National Cancer Institute · USCenter for Cancer Research · US

Funding

Growth Factor Imaging and PhotoimmunotherapyZIABC010656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2024
$31.6M
Cancer-cell specific therapy: photo-immunotherapyZIABC011513 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KOBAYASHI, HISATAKA · 2013 to 2025
$15.5M
Intramural NIH HHS ZIA BC011513
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy. Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photoabsorber conjugate (APC). Here, we describe the efficacy of NIR-PIT, using a fully human IgG

Indexed as

AnimalsAntigens, SurfaceCell Line, TumorFemaleGlutamate Carboxypeptidase IIHumansImmunotherapyMaleMiceMice, NudePhototherapyProstatic NeoplasmsAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase II

Identifiers

PMID28588059
PMCPMC5581714
OpenAlexW2624126191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.