Evidence map›Paper›PMID 28588025›Full record

ArticleThe Journal of biological chemistry2017

Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na

Asghar M Razavi, Lucie Delemotte, Joshua R Berlin, Vincenzo Carnevale, Vincent A Voelz

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Active conformations of neuronal NaNature communications · 2026
    Article
  2. Specific protonation of acidic residues confers KThe Journal of biological chemistry · 2024
    Article
  3. Structure and function of HNature communications · 2022
    Article
  4. Article
  5. NaMolecules (Basel, Switzerland) · 2021
    Review
  6. A Model for the Homotypic Interaction between NaInternational journal of molecular sciences · 2019
    Article
  7. Cholesterol depletion inhibits NaThe Journal of biological chemistry · 2019
    Article
  8. Article
  9. KScientific reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asghar M RazaviDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122.
Lucie DelemotteInstitute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania 19122; Science for Life Laboratory, Department of Theoretical Physics, KTH Royal Institute of Technology, Stockholm 11428, Sweden.
Joshua R BerlinDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103.
Vincenzo CarnevaleDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122; Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania 19122. Electronic address: vincenzo.carnevale@temple.edu.
Vincent A VoelzDepartment of Chemistry, Temple University, Philadelphia, Pennsylvania 19122; Institute for Computational Molecular Science, Temple University, Philadelphia, Pennsylvania 19122. Electronic address: voelz@temple.edu.

Funding

MOLECULAR MECHANISM OF ION TRANSPORT BY THE NA, K-PUMPR01GM057253 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BERLIN, JOSHUA R · 1999 to 2006
$2.2M
Computer Cluster for Computational Biology and BiophysicsS10OD020095 · OD · TEMPLE UNIV OF THE COMMONWEALTH · PI LEVY, RONALD · 2015 to 2015
$442k
NIGMS NIH HHS R01 GM057253NIH HHS S10 OD020095
6 · The paper itself

Abstract

Na

Indexed as

Molecular Dynamics SimulationThermodynamicsAnimalsAnionsBinding SitesCytoplasmModels, MolecularProtein ConformationSodium-Potassium-Exchanging ATPaseSwineAnionsSodium-Potassium-Exchanging ATPaseanion binding sitefree energy perturbationmembrane transportmembrane transportermolecular dynamicsNa+/K+-ATPasepotassium transportprotonationselectivitysodium transport

Identifiers

PMID28588025
PMCPMC5535017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.